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JAMP DOXEPIN is a brand name for Doxepin, supplied as a capsule. The medicine, its uses, side effects and dosage are the same regardless of brand.
Verbatim from this product's HC label. Tap a section to expand.
Although some of the adverse reactions included in the following list have not been reported with doxepin hydrochloride pharmacological similarities among the tricyclic antidepressants require that each of the reactions be considered when prescribing JAMP Doxepin.
Behavioral - Drowsiness, fatigue, excitement, agitation, restlessness, insomnia, nightmares, hypomania, anxiety, confusion, disorientation, disturbed concentration, delusions, hallucinations, activation of latent psychosis. Neurological - Seizures, alteration in EEG patterns, dizziness, tremors, extrapyramidal symptoms, numbness, tingling, paresthesias of the extremities, peripheral neuropathy, tinnitus, syndrome of inappropriate ADH (antidiuretic hormone) secretion, ataxia, tardive dyskinesia.
Cardiovascular - Hypotension, hypertension, tachycardia, palpitations. A quinidine-like effect and other reversible ECG changes such as flattening or inversion of T-waves, bundle branch block, depressed S-T segments, prolonged conduction time and asystole, arrhythmias, heart block, fibrillation, myocardial infarction, stroke and unexpected death in patients with cardiovascular disorders have been reported with other tricyclic antidepressants.
Autonomic - Dry mouth, blurred vision, disturbances of accommodation, mydriasis, constipation, nasal stuffiness, delayed micturition, sublingual adenitis, paralytic ileus, urinary retention, dilation of the urinary tract, precipitation of latent and aggravation of existing glaucoma, vertigo.
Endocrine - Increased or decreased libido, impotence, menstrual irregularity, testicular swelling, breast enlargement and galactorrhea in the female, gynecomastia in the male, elevation and lowering of blood sugar levels. Allergic or Toxic - Pruritus, skin rash, photosensitization, edema, drug fever, leukopenia, urticaria, petechiae, obstructive jaundice and bone marrow depression, including agranulocytosis, eosinophilia, purpura and thrombocytopenia.
Gastrointestinal - Nausea, epigastric distress, vomiting, flatulence, abdominal pain, diarrhea, peculiar taste, stomatitis. Miscellaneous - Weakness, chills, flushing, headache, weight gain or loss, excessive appetite, anorexia, increased perspiration, urinary frequency, lacrimation, alopecia, parotid swelling, black tongue, hepatitis, exacerbation of asthma and hyperpyrexia (in association with chlorpromazine).
Withdrawal Symptoms - Abrupt cessation of treatment with tricyclic antidepressants after prolonged administration may produce nausea, headache and malaise. These symptoms are not indicative of addiction. ca/drug-device-reporting) for information on how to report online, by mail or by fax; or • Calling toll-free at 1-866-234-2345.
NOTE:
Contact your healthcare professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice. SYMPTOMS AND TREATMENT OF OVER DOSAGE Symptoms - Excessive drowsiness leading to minor alterations of consciousness and even unresponsiveness could be an early indication of excessive dosage.
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Doxepin in Canada.
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Brand names are compiled from public regulatory records for active-ingredient mapping only. Drugvu is not affiliated with any manufacturer. This is not medical advice.
However, overdosage with JAMP Doxepin (doxepin hydrochloride) is more likely to be manifested by increased psychomotor agitation and convulsions leading to apnea and coma. The ECG changes (broadening of QRS and T- wave abnormalities) tend to be a late finding and are not always accompanied by cardiovascular hemodynamic changes.
Treatment - In general, treatment of overdosage should be symptomatic and supportive. Cardiac arrhythmias and CNS involvement pose the greatest threat with tricyclic antidepressant overdosage and may occur suddenly even when initial symptoms appear to be mild.
Therefore, patients who may have ingested an overdosage of doxepin hydrochloride, particularly children, should be hospitalized and kept under close surveillance. If the patient is conscious, induced emesis followed by gastric lavage, with appropriate precautions to prevent pulmonary aspiration, should be accomplished as soon as possible.
Following lavage, activated charcoal may be administered to reduce absorption. An adequate airway should be established in comatose patients and assisted ventilation instituted, if necessary. The possibility of occurrence of seizures should be kept in mind.
External stimulation should be minimized to reduce the tendency to convulsions. Convulsions, should they occur, may respond to standard anticonvulsant therapy; however, barbiturates should be avoided since they may potentiate respiratory depression, particularly in children, and aggravate hypotension and coma.
ECG monitoring in an intensive care unit is recommended in all patients, particularly in the presence of ECG abnormalities, and should be maintained for several days after the cardiac rhythm has returned to normal. A patient who has ingested a toxic overdose of a tricyclic antidepressant may remain medically and psychiatrically unstable for several days due to sustained excessive drug levels.
Unexpected cardiac deaths have occurred up to 6 days after Product Monograph JAMP Doxepin (doxepin hydrochloride) Product Monograph Page 8 of 15 overdosage with other antidepressants. The QRS interval of the electrocardiogram appears to be a reliable correlate of the severity of overdosage.
If the QRS interval exceeds 100 milliseconds any time during the first 24 hours after overdosage, cardiac function should be continuously monitored for 5 or 6 days. Because of its effect on cardiac conduction, digitalis should be used only with caution.
If rapid digitalization is required for the treatment of congestive heart failure, special care should be exercised in using the drug. Shock should be treated with supportive measures such as intravenous […]