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CILOXAN is a brand name for Ciprofloxacin, supplied as a solution. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: AND CLINICAL USE ..............................................................................3 CONTRAINDICATIONS ...................................................................................................4 WARNINGS AND PRECAUTIONS…
Verbatim from this product's HC label. Tap a section to expand.
Clinical Trial Adverse Drug Reactions Because clinical trials are conducted under very specific conditions the adverse reaction rates observed in the clinical trials may not reflect the rates observed in practice and should not be compared to the rates in the clinical trials of another drug.
Adverse drug reaction information from clinical trials is useful for identifying drug-related adverse events and for approximating rates. During clinical studies, treatment related adverse events to CILOXAN solution and ointment were mild, infrequent in occurrence and non-serious in nature, and did not lead to premature discontinuation of therapy.
2%). 5 and 1% incidence were: lid margin crusting, crystals/ scales, erythema/redness, dryness, discharge, corneal staining, keratopathy/keratitis, hyperemia/congestion and tearing. 8%) patients. The precipitate required no adjunctive therapy and resolved spontaneously with continued ciprofloxacin use.
Other rarely reported events related or possibly related to CILOXAN solution included: ocular congestion, photophobia, pain, vision decrease, chemosis, corneal infiltrate, inflammation, blurred vision, corneal toxicity, allergy, intolerance, lid edema, heavy sensation, swelling, conjunctival reaction, numbing sensation, conjunctivitis, punctate epithelial erosion, worsened infiltrate, and headache.
2%). 0% of patients included: pruritus, eye pain, tearing, photophobia, allergic reactions, dry eye, decreased visual acuity, lid erythema, corneal staining, keratoconjunctivitis, keratopathy, corneal lesion, epitheliopathy, ocular edema, irritation, foreign body sensation, nausea, dermatitis and metallic taste.
CILOXAN® Product Monograph 8 Post-Market Adverse Drug Reactions The following additional adverse reactions were seen with CILOXAN solution or ointment in subsequent clinical trials: Ear and labyrinth disorders: ear pain; Eye disorders: asthenopia, conjunctival edema, corneal epithelium defect, diplopia, eyelid exfoliation, hordeolum, hypoesthesia eye, punctate keratitis, vital dye staining cornea present; Gastrointestinal disorders: abdominal pain, diarrhea; Nervous system disorders: dizziness; Respiratory, thoracic and mediastinal disorders: paranasal sinus hypersecretion, rhinitis.
The following additional adverse reactions were seen with CILOXAN solution or ointment via spontaneous reporting. Reliable estimates of the frequencies of spontaneous reactions cannot be determined because they are reported voluntarily from a population of uncertain size: Musculoskeletal and connective tissue disorders: tendon disorder.
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Ciprofloxacin in Canada.
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DRUG INTERACTIONS Specific drug interaction studies have not been conducted with CILOXAN solution or ointment. However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, enhance the effects of the oral anticoagulant, warfarin and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving cyclosporin concomitantly.
DOSAGE AND ADMINISTRATION Recommended Dose Solution:
Conjunctivitis (Adults and Children 1 year and older): Instill one or two drops of CILOXAN solution into the conjunctival sac(s) every two hours while awake for two days and then two drops every four hours while awake for 5 days.
Corneal Ulcer (Adults and Children 12 years and older):
Instill two drops of CILOXAN solution into the affected eye(s) every 15 minutes for the first six hours and then two drops into the affected eye(s) every 30 minutes for the remainder of the first day. On the second day, instill two drops in the affected eye(s) hourly.
On the third through the fourteenth day, place two drops in the affected eye(s) every four hours. If corneal reepithelialization has not occurred after 14 days, the continuation of the dosing regimen is at the discretion of the attending physician.
CILOXAN® Product Monograph 9 Ointment:
Conjunctivitis (Adults and Children 1 year and older): Apply a 1/2" ribbon of CILOXAN ointment into the conjunctival sac(s) three times a day on the first two days and then apply a 1/2" ribbon two times a day for the next five days.
Corneal Ulcer (Adults and Children 12 years and older):
Apply a 1/2" ribbon of CILOXAN ointment into the conjunctival sac(s) every 1-2 hours around the clock on the first two days, then apply a 1/2" ribbon every 4 hours for up to 12 days. If corneal reepithelialization has not occurred after 12 days, the continuation of the dosing regimen is at the discretion of the attending physician.
Missed Dose:
If a dose is missed, treatment should be continued as soon as possible. However if it is almost time for the next dose, the missed dose should be skipped. Do not use a double dose to make up for the one missed.
Administration Solution and ointment:
Patients should be advised to avoid contamination of the dispensing tip. CILOXAN® Product Monograph 10 OVERDOSAGE A topical overdosage of CILOXAN is considered to be a remote possibility. Discontinue medication when […]