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🏠›Paroxetine›Interaction with Amitriptyline

Paroxetine + Amitriptyline

Drug interaction

Major interaction

A major drug-drug interaction between Paroxetine and Amitriptyline is recorded in public interaction data. Severity reflects the source classification; it does not describe your individual risk. Do not start, stop, or change either medicine based on this page.

What “major” means

A major interaction can cause a clinically significant - sometimes serious - effect. Prescribers usually avoid this combination, or use it only with close monitoring and dose adjustments.

What to do

Do not combine these on your own. If both have been prescribed, tell your pharmacist or doctor so they can confirm it is intended and watch for problems.

The two medicines

Active ingredient

Paroxetine

Selective Serotonin Reuptake Inhibitors

Uses, side effects, dosage →· 712 recorded interactions

Active ingredient

Amitriptyline

Non-Selective Monoamine Reuptake Inhibitors

Uses, side effects, dosage →· 703 recorded interactions

Source

DDInter 2.0 (CC-BY 4.0, https://ddinter.scbdd.com)

This is not medical advice. Drugvu is an independent aggregator of public records.

Paroxetine and Amitriptyline: Major Interaction - Drugvu