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Methotrexate and Hydrochlorothiazide: Moderate Interaction - Drugvu

🏠›Methotrexate›Interaction with Hydrochlorothiazide

Methotrexate + Hydrochlorothiazide

Drug interaction

Moderate interaction

A moderate drug-drug interaction between Methotrexate and Hydrochlorothiazide is recorded in public interaction data. Severity reflects the source classification; it does not describe your individual risk. Do not start, stop, or change either medicine based on this page.

What “moderate” means

A moderate interaction can matter in some people. The combination is sometimes used, but usually with caution - monitoring, timing changes, or dose adjustments.

What to do

Mention this combination to your pharmacist or prescriber. Do not stop either medicine without advice.

Side effects reported for both

Methotrexate and Hydrochlorothiazide are each reported to cause the effects below. Taking them together can make these more likely or more pronounced - one of the ways a drug interaction matters.

PainArthralgiaFatigueNauseaHeadacheDiarrhoeaVomiting

Compiled from public adverse-event reports; an overlap, not a confirmed causal mechanism.

The two medicines

Active ingredient

Methotrexate

Folic Acid Analogues

Uses, side effects, dosage →· 702 recorded interactions

Active ingredient

Hydrochlorothiazide

Thiazides, Plain

Uses, side effects, dosage →· 642 recorded interactions

Source

DDInter 2.0 (CC-BY 4.0, https://ddinter.scbdd.com)

This is not medical advice. Drugvu is an independent aggregator of public records.