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🏠›Codeine›Interaction with Methadone

Codeine + Methadone

Drug interaction

Major interaction

A major drug-drug interaction between Codeine and Methadone is recorded in public interaction data. Severity reflects the source classification; it does not describe your individual risk. Do not start, stop, or change either medicine based on this page.

What “major” means

A major interaction can cause a clinically significant - sometimes serious - effect. Prescribers usually avoid this combination, or use it only with close monitoring and dose adjustments.

What to do

Do not combine these on your own. If both have been prescribed, tell your pharmacist or doctor so they can confirm it is intended and watch for problems.

The two medicines

Active ingredient

Codeine

Opium Alkaloids and Derivatives

Uses, side effects, dosage →· 429 recorded interactions

Active ingredient

Methadone

Drugs Used In Opioid Dependence

Uses, side effects, dosage →· 660 recorded interactions

Source

DDInter 2.0 (CC-BY 4.0, https://ddinter.scbdd.com)

This is not medical advice. Drugvu is an independent aggregator of public records.

Codeine and Methadone: Major Interaction - Drugvu