Verapamil

Verapamil is indicated for the treatment and prophylaxis of angina pectoris. It may be used in the treatment and prophylaxis of paroxysmal supraventricular tachycardia, atrial fibrillation and atrial flutter; (verapamil should not be used where atrial flutter/fibrillation complicates Wolff-Parkinson-White syndrome).

Verapamil may also be used in the management of mild to moderate hypertension and renal hypertension.

INDICATIONS AND USAGE

Verapamil Hydrochloride Tablets are indicated for the treatment of the following:

Angina 1. Angina at rest including: – Vasospastic (Prinzmetal’s variant) angina – Unstable (crescendo, pre-infarction) angina 2. Chronic stable angina (classic effort-associated angina) Arrhythmias 1. In association with digitalis for the control of ventricular rate at rest and during stress in patients with chronic atrial flutter and/or atrial fibrillation (see WARNINGS; Accessory bypass tract ) 2.

Prophylaxis of repetitive paroxysmal supraventricular tachycardia Essential hypertension: Verapamil is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions.

These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes, including this drug. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake.

Verapamil Hydrochloride Injection USP (verapamil hydrochloride) is indicated for life-threatening cardiac arrhythmias under the following conditions: o Rapid conversion to sinus rhythm of paroxysmal supraventricular tachycardias, including those associated with accessory bypass tracts (Wolff-Parkinson-White [WPW] and Lown-Ganong-Levine [LGL] syndromes).

g. Valsalva manœuvre) should be attempted prior to verapamil hydrochloride administration. o Temporary control of rapid ventricular rate in atrial flutter or atrial fibrillation except when the atrial flutter and/or atrial fibrillation are associated with accessory bypass tracts (Wolff-Parkinson-White and Lown-Ganong-Levine syndromes).

0%) of patients treated with verapamil hydrochloride react with life- threatening adverse responses (rapid ventricular rate in atrial flutter/fibrillation and an accessory bypass tract, marked hypotension, or extreme bradycardia/asystole) (see