Tromethamine
Active ingredient · 2 therapeutic classes
- Drug class
- Solutions Affecting The Electrolyte Balance
- Availability
- Prescription only
- Routes
- Intravenous
- Markets covered
- 1
- Products on record
- 1
- FDA reports (12 mo)
- 480
Overview
Plain-language summary, compiled from the cited regulatory records
Tromethamine is a medication classified as a solution affecting electrolyte balance [1]. It is approved for the prevention and correction of metabolic acidosis [1]. In specific situations, it may help sustain vital functions, allowing time for treatment of the underlying condition [1].
One approved use is for metabolic acidosis associated with cardiac bypass surgery [1]. Tromethamine Injection has shown benefit in correcting metabolic acidosis that can occur during or immediately after these surgical procedures [1].
In the past 12 months, there have been 480 adverse event reports for tromethamine [2]. The most frequently reported adverse events include nausea, off-label use, vomiting, fatigue, and headache [2].
This is not medical advice. Consult a qualified healthcare professional.
Regulatory status by market
| Market | Regulator | Products | Last revision |
|---|---|---|---|
| US United States | FDA | 1 | January 7, 2026 |
USUnited States· FDA
1 product
Uses
INDICATIONS AND USAGE
Tromethamine Injection is indicated for the prevention and correction of metabolic acidosis. In the following conditions it may help to sustain vital functions and thus provide time for treatment of the primary disease: Metabolic Acidosis Associated with Cardiac Bypass Surgery.
Tromethamine Injection has been found to be primarily beneficial in correcting metabolic acidosis which may occur during or immediately following cardiac bypass surgical procedures. Correction of Acidity of ACD Blood in Cardiac Bypass Surgery.
It is well known that ACD blood is acidic and becomes more acidic on storage. Tromethamine effectively corrects this acidity. Tromethamine Injection may be added directly to the blood used to prime the pump-oxygenator. When ACD blood is brought to a normal pH range the patient is spared an initial acid load.
Additional tromethamine may be indicated during cardiac bypass surgery should metabolic acidosis appear. Metabolic Acidosis Associated with Cardiac Arrest. Acidosis is nearly always one of the consequences of cardiac arrest and, in some instances, may even be a causative factor in arrest.
Drug interactions
Known interactions involving Tromethamine. Select one for details. This list is informational and not a complete interaction checker.
Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.
Sources & citations
- [1]FDA DailyMed · 082b1104-502b-47… · revised January 7, 2026 [PDF]
- [2]OpenFDA adverse-event reports (US), 12 months ending June 4, 2026.
Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.