Tizanidine
Other Centrally Acting Agents
- Drug class
- Other Centrally Acting Agents
- Availability
- Prescription only
- Routes
- Oral
- Markets covered
- 3
- Products on record
- 21
- FDA reports (12 mo)
- 2,251
Overview
Plain-language summary, compiled from the cited regulatory records
Tizanidine is a medication classified as a centrally acting agent [1]. It functions as a central alpha-2-adrenergic agonist [1]. Tizanidine is approved for the management of spasticity in adult patients [1].
This medication is available under various brand names [N]. In the past 12 months, there have been 2,251 adverse event reports associated with tizanidine [2]. The most frequently reported adverse events include nausea, toxicity to various agents, fatigue, completed suicide, and off-label use [2].
This is not medical advice. Consult a qualified healthcare professional.
Regulatory status by market
| Market | Regulator | Products | Last revision |
|---|---|---|---|
| GB United Kingdom | MHRA | 10 | May 29, 2026 |
| US United States | FDA | 8 | April 14, 2026 |
| CA Canada | Health Canada | 3 | December 31, 2025 |
GBUnited Kingdom· MHRA
10 products
Uses
Treatment of spasticity associated with multiple sclerosis or with spinal cord injury or disease.
How to take
USUnited States· FDA
8 products
Uses
1 INDICATIONS AND USAGE Tizanidine is indicated for the treatment of spasticity in adults. Tizanidine is a central alpha-2-adrenergic agonist indicated for the treatment of spasticity. (1)
How to take
CACanada· Health Canada
3 products
Uses
AND CLINICAL USE .............................................................................................. 3 CONTRAINDICATIONS ...................................................................................................................
3 WARNINGS AND PRECAUTIONS .................................................................................................. 4 ADVERSE REACTIONS....................................................................................................................
8 DRUG INTERACTIONS .................................................................................................................. 13 DOSAGE AND ADMINISTRATION ..............................................................................................
14 OVERDOSAGE ................................................................................................................................ 15 ACTION AND CLINICAL PHARMACOLOGY.............................................................................
Drug interactions
Known interactions involving Tizanidine. Select one for details. This list is informational and not a complete interaction checker.
Showing 240 of 600. Type above to find a specific drug.
Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.
Sources & citations
- [1]MHRA (UK) · PL002890648 · revised March 28, 2025
- [2]FDA DailyMed · 01c0d3d3-2373-a1… · revised March 11, 2025 [PDF]
- [3]Health Canada (DPD) · 02536765 · revised March 22, 2025
- [4]OpenFDA adverse-event reports (US), 12 months ending June 4, 2026.
Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.