Thiamine
Vitamin B1, Plain
Sold as METATONE
- Drug class
- Vitamin B1, Plain
- Availability
- Prescription only
- Routes
- Intramuscular, Intravenous
- Markets covered
- 2
- Products on record
- 25
Overview
Plain-language summary, compiled from the cited regulatory records
Thiamine, also known as Vitamin B1, is a vitamin that plays a crucial role in the body's metabolism [1]. It belongs to the drug class of Vitamin B1, Plain (A11DA) [1].
Thiamine hydrochloride injection is approved for treating thiamine deficiency and beriberi. This includes both dry beriberi, which primarily affects the nervous system, and wet beriberi, which primarily impacts the cardiovascular system [1]. It is particularly indicated when a rapid replenishment of thiamine is necessary, such as in cases of Wernicke’s encephalopathy, infantile beriberi with acute collapse, cardiovascular conditions stemming from thiamine deficiency, or pregnancy-related neuritis accompanied by vomiting [1].
Thiamine is available under various brand names [1].
This is not medical advice. Consult a qualified healthcare professional.
Regulatory status by market
| Market | Regulator | Products | Last revision |
|---|---|---|---|
| GB United Kingdom | MHRA | 23 | May 29, 2026 |
| US United States | FDA | 2 | September 30, 2025 |
GBUnited Kingdom· MHRA
23 products
Uses
Thiamine deficiency conditions where oral therapy is not possible. Treatment of Wernicke´s encephalopathy associated with Alcohol addiction and/or alcohol withdrawal syndrome and prevention of Wernicke-Korsakoff syndrome. For the treatment of peripheral neuropathy (dry beriberi) and heart failure (wet beriberi) due to thiamine malabsorption.
For the treatment of anorexia – refeeding syndrome.
How to take
USUnited States· FDA
2 products
Uses
INDICATIONS
Thiamine hydrochloride injection is effective for the treatment of thiamine deficiency or beriberi whether of the dry (major symptoms related to the nervous system) or wet (major symptoms related to the cardiovascular system) variety.
Thiamine hydrochloride injection should be used where rapid restoration of thiamine is necessary, as in Wernicke’s encephalopathy, infantile beriberi with acute collapse, cardiovascular disease due to thiamine deficiency, or neuritis of pregnancy if vomiting is severe.
It is also indicated when giving IV dextrose to individuals with marginal thiamine status to avoid precipitation of heart failure. Thiamine hydrochloride injection is also indicated in patients with established thiamine deficiency who cannot take thiamine orally due to coexisting severe anorexia, nausea, vomiting, or malabsorption.
Thiamine hydrochloride injection is not usually indicated for conditions of decreased oral intake or decreased gastrointestinal absorption, because multiple vitamins should usually be given.
Sources & citations
- [1]MHRA (UK) · PL554690002 · revised January 30, 2026
- [2]FDA DailyMed · 0f38c4ba-cebf-49… · revised September 30, 2025 [PDF]
Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.