Tetrabenazine

Tetrabenazine is indicated for hyperkinetic motor disorders with Huntington’s chorea.

General The initial dose should be low, and dosage should be titrated slowly according to the tolerance and responsiveness of the individual patient. Once a stable dose has been achieved, treatment should be reassessed periodically in the context of the patient’s underlying condition and their concomitant medications.

5 mg (half a tablet) two to three times a day is recommended. 5 mg a day at weekly intervals, until the maximal tolerated and effective dose is reached for the individual and may have to be up/down titrated depending on individual tolerance (see ADVERSE REACTIONS).

For some patients, a slower titration may be more appropriate (see Special Populations, CYP2D6 Poor Metabolizers, and Geriatrics below). d. In very rare cases, a 200 mg dose has been reached (the maximum recommended dose in some publications).

If there is no improvement at the maximal tolerated dose in seven days, it is unlikely that NITOMAN will be of benefit to the patient, either by increasing the dose or by extending the duration of treatment. Re-initiation of NITOMAN After Treatment Interruption Following treatment interruption of greater than five days, NITOMAN should be re-titrated when resumed.