Succinylated Gelatin: Uses, Side Effects, Dosage - Drugvu

ℹ️ Compiled from public regulatory records · Last regulator revision: May 29, 2026🚩 Report this page

Succinylated Gelatin

Active ingredient

Sold as VOLPLEX

GB MHRA

Drug class: -
Availability: See label
Markets covered: 1
Products on record: 3

Overview

Succinylated Gelatin is an active pharmaceutical ingredient. The information below is compiled per regulator from the product labels on record, with direct links to the original documents.

Regulatory status by market

Market	Regulator	Products	Last revision
GB United Kingdom	MHRA	3	May 29, 2026

GBUnited Kingdom· MHRA

3 products

Uses

GBOfficial regulatory label· revised July 25, 2025[1]

Volplex is a colloidal plasma substitute indicated for the initial management of hypovolaemic shock caused by, for example, haemorrhage, acute trauma or surgery, burns, sepsis, peritonitis, pancreatitis or crush injury. Volplex may be used in the initial treatment of blood loss during pregnancy where plasma volume replacement is needed.

How to take

Sources & citations

[1]MHRA (UK) · PL514630104 · revised July 25, 2025

Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.

Side effects & warnings

GBOfficial regulatory label· Adverse reactions· revised July 25, 2025[1]

3 notably for hypersensitivity to galactose- α-1,3-galactose (alpha-Gal) and allergy to red meat and offal). A list of rare undesirable effects that have been associated with the administration of Volplex is given beneath; Rare effects (>1 in 10,000 to <1 in 1,000) Immune system disorders Anaphylactic reaction Anaphylactoid reaction Nervous system disorders Tremor Cardiac disorders Tachycardia Vascular disorders Hypotension Hypertension Respiratory, thoracic and mediastinal disorders Wheezing Dyspnoea Hypoxia Skin and subcutaneous disorders Urticarial reactions Sweating General disorders and administration site reactions Chills Pyrexia Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important.
It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

GBOfficial regulatory label· Warnings and precautions· revised July 25, 2025[1]

(i) Severe anaphylactic or anaphylactoid reactions have been reported following the intravenous administration of succinylated gelatin. These are rare, having an incidence of between 1 in 6,000 and 1 in 13,000 units. However, they may be more likely to occur if Volplex is given rapidly to normovolaemic patients, and may be assumed to be more hazardous in patients with known allergic conditions such as asthma.
Due to possible cross-reactions involving the allergen galactose-alpha-1,3-galactose (alpha-Gal), the risk of sensitization and consequent anaphylactic reaction to gelatin- containing solutions could be highly increased in patients with history of allergy to red meat (mammal meat) and offal and/or tested positive for anti-alpha-Gal IgE antibodies.
3) Treatment: The infusion of Volplex should be stopped. g. g. chlorpheniramine 10 – 20 mg slowly intravenously) should be considered. (ii) Caution should be exercised in infusing Volplex in any patient liable to develop circulatory overload (for example, congestive cardiac failure or renal failure with oliguria or anuria) since excessive volumes may give rise to circulatory overload and electrolyte imbalance.
Treatment:
The infusion of Volplex should be stopped and the patient treated symptomatically. Electrolytes should be monitored. If necessary, a diuretic can be given to promote fluid loss. Decreased urinary output secondary to shock is not a contraindication unless there is no improvement in urine output after the initial dose of Volplex.
5% of the WHO recommended maximum daily dietary intake for sodium. The maximum daily dose of this product is equivalent to 354% of the WHO recommended maximum daily intake for sodium. Volplex is considered high in sodium. This should be particularly taken into account for those on a low salt diet.

This is not medical advice. Consult a qualified healthcare professional.