Progesterone
Pregnen (4) Derivatives
Sold as CRINONE · PROMETRIUM · ENDOMETRIN · UTROGESTAN
- Drug class
- Pregnen (4) Derivatives
- Availability
- Prescription and OTC
- Routes
- Oral, Vaginal, Intramuscular
- Markets covered
- 3
- Products on record
- 85
- FDA reports (12 mo)
- 2,336
Overview
Plain-language summary, compiled from the cited regulatory records
Progesterone is a medication belonging to the pregnen (4) derivatives drug class [1]. It is approved for specific uses in postmenopausal women and for treating secondary amenorrhea [1].
Specifically, progesterone capsules are indicated for the prevention of endometrial hyperplasia in postmenopausal women who are also taking conjugated estrogens and have not had a hysterectomy [1]. Additionally, it is approved for the treatment of secondary amenorrhea [1].
In the past 12 months, there were 2,336 adverse event reports associated with progesterone [2]. Common adverse events reported include foetal exposure during pregnancy, headache, off-label use, reports of the drug being ineffective, and pain [2].
This is not medical advice. Consult a qualified healthcare professional.
Regulatory status by market
| Market | Regulator | Products | Last revision |
|---|---|---|---|
| GB United Kingdom | MHRA | 61 | May 29, 2026 |
| CA Canada | Health Canada | 14 | May 28, 2026 |
| US United States | FDA | 10 | May 13, 2026 |
GBUnited Kingdom· MHRA
61 products
Uses
Progesterone is indicated for adjunctive use with oestrogen in post-menopausal women with an intact uterus, as hormone replacement therapy (HRT).
How to take
CACanada· Health Canada
14 products
Uses
2 Geriatrics 07/2025
How to take
USUnited States· FDA
10 products
Uses
INDICATIONS AND USAGE
Progesterone capsules are indicated for use in the prevention of endometrial hyperplasia in nonhysterectomized postmenopausal women who are receiving conjugated estrogens tablets. They are also indicated for use in secondary amenorrhea.
How to take
Drug interactions
Known interactions involving Progesterone. Select one for details. This list is informational and not a complete interaction checker.
Showing 240 of 315. Type above to find a specific drug.
Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.
Sources & citations
- [1]MHRA (UK) · PL001421330 · revised May 15, 2026
- [2]Health Canada (DPD) · 02166704 · revised August 15, 2025
- [3]FDA DailyMed · 0aeb0f0f-2749-41… · revised May 16, 2025 [PDF]
- [4]OpenFDA adverse-event reports (US), 12 months ending June 4, 2026.
Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.