Procyclidine: Uses, Side Effects, Dosage - Drugvu

ℹ️ Compiled from public regulatory records · Last regulator revision: May 15, 2026🚩 Report this page

Procyclidine

Tertiary Amines

GB MHRA

Drug class: Tertiary Amines
Availability: See label
Markets covered: 1
Products on record: 20

Overview

Procyclidine is an active pharmaceutical ingredient in the Tertiary Amines group (N04AA). The information below is compiled per regulator from the product labels on record, with direct links to the original documents.

Regulatory status by market

Market	Regulator	Products	Last revision
GB United Kingdom	MHRA	20	May 15, 2026

GBUnited Kingdom· MHRA

20 products

Uses

GBOfficial regulatory label· revised May 15, 2026[1]

g. idiopathic (paralysis agitans), postencephalitic and arteriosclerotic disease. Procyclidine is also indicated for the control of extrapyramidal symptoms induced by neuroleptic drugs including pseudo-Parkinsonism, acute dystonic reactions and akathisia.

How to take

Drug interactions

Known interactions involving Procyclidine. Select one for details. This list is informational and not a complete interaction checker.

Potassium Chloride Potassium Citrate Topiramate Zonisamide Acebutolol Acetylcholine Aclidinium Acrivastine Alfentanil Alprazolam Amantadine Ambenonium Amitriptyline Amobarbital Amoxapine Apraclonidine Arbutamine Aripiprazole Asenapine Atenolol Atropine Azatadine Baclofen Benzhydrocodone Betaxolol Bethanechol Biperiden Bisoprolol Botulinum Toxin Type A Botulinum Toxin Type B Brexanolone Brexpiprazole Brimonidine Brivaracetam Bromocriptine Brompheniramine Buprenorphine Buspirone Butabarbital Butalbital Butorphanol Cannabidiol Carbamazepine Carbamoylcholine Carbinoxamine Cariprazine Carisoprodol Carteolol Carvedilol Cenobamate Cetirizine Cevimeline Chlorcyclizine Chlordiazepoxide Chlormezanone Chlorphenesin Chlorpheniramine Chlorpromazine Chlorzoxazone Citalopram Clemastine Clidinium Clobazam Clomipramine Clonazepam Clonidine Clorazepate Clozapine Codeine Cyclizine Cyclobenzaprine Cyproheptadine Dantrolene Darifenacin Demecarium Desipramine Desvenlafaxine Deutetrabenazine Dexbrompheniramine Dexmedetomidine Dextromethorphan Dezocine Diazepam Dicyclomine Dihydrocodeine Dimenhydrinate Diphenhydramine Disopyramide Donepezil Doxepin Doxylamine Dronabinol Droperidol Duloxetine Edrophonium Eluxadoline Escitalopram Esketamine Eslicarbazepine Estazolam Eszopiclone Ethanol Ethchlorvynol Ethosuximide Ethotoin Ezogabine Fentanyl Fesoterodine Flavoxate Flibanserin Fluoxetine Fluphenazine Flurazepam Fluvoxamine Fosphenytoin Gabapentin Galantamine Glycopyrronium Guanidine Halazepam Haloperidol Homatropine Hydrocodone Hydromorphone Hydroxyzine Hyoscyamine Iloperidone Imipramine Ipratropium Isoflurophate Ketamine Ketoconazole Labetalol Lamotrigine Lasmiditan Lemborexant Levetiracetam Levocetirizine Levodopa Levorphanol Lofexidine Loperamide Lorazepam Loxapine Lumateperone Lurasidone Maprotiline Meclizine Memantine Mepenzolate Meperidine Mephenytoin Mephobarbital Meprobamate Mesoridazine Metaxalone Methadone Methdilazine Methocarbamol Methohexital Methotrimeprazine Methscopolamine Methsuximide Metoclopramide Metoprolol Metyrosine Midazolam Mirtazapine Molindone Morphine Nabilone Nadolol Nalbuphine Nebivolol Nefazodone Neostigmine Nortriptyline Olanzapine Oliceridine Olopatadine Opicapone Opium Orphenadrine Oxazepam Oxcarbazepine Oxybutynin Oxycodone Oxymorphone Paliperidone Paraldehyde Penbutolol Pentazocine Pentobarbital Perampanel Pergolide Perphenazine Phenindamine Phenobarbital Phensuximide Phenylephrine Phenyltoloxamine Phenytoin Physostigmine Pilocarpine Pimozide Pindolol Pramlintide Pregabalin Primidone Prochlorperazine Promazine Promethazine Propantheline Propiomazine Propoxyphene Propranolol Protriptyline Prucalopride Pyridostigmine Pyrilamine Quazepam Quetiapine Ramelteon Rasagiline Remifentanil Remimazolam Revefenacin Risperidone Rivastigmine Rotigotine Rufinamide Scopolamine Secobarbital Sertraline Solifenacin Sotalol Stiripentol Sufentanil Suvorexant Tacrine

Showing 240 of 292. Type above to find a specific drug.

Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.

Sources & citations

[1]MHRA (UK) · PL248370176 · revised May 15, 2026

Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.

Side effects & warnings

GBOfficial regulatory label· Adverse reactions· revised May 15, 2026[1]

Undesirable effects are listed below by system organ class and frequency. For this preparation there is no modern clinical documentation which can be used as support for determining the frequency of adverse reactions. Very common (≥1/10); Common (≥1/100 to <1/10); Uncommon (≥1/1,000 to <1/100); Rare (≥1/10,000 to <1/1,000); Very rare (<1/10,000); Not known (cannot be estimated from the available data).
System Organ Class Frequency Side effects Uncommon Agitation, anxiety, nervousness, confusion, disorientation, hallucinations Psychiatric disorders Rare Psychotic disorder Nervous system disorders Uncommon Dizziness, memory impairment, impaired cognition Eye disorders Common Blurred vision Common Dry mouth, constipationGastrointestinal disorders Uncommon Nausea, vomiting, gingivitis Skin and subcutaneous tissue disorders Uncommon Rash Renal and urinary disorders Common Urinary retention The main undesirable effects are those to be expected from any anticholinergic agent, these are generally reversible on reducing the dosage.
With high doses of procyclidine dizziness, mental confusion, impaired cognition and memory, disorientation, anxiety, agitation and hallucinations may occur. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important.
It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

GBOfficial regulatory label· Warnings and precautions· revised May 15, 2026[1]

As with all anticholinergics the benefit/risk ratio should be assessed when prescribing procyclidine in patients with existing angle-closure (narrow angle) glaucoma or those considered to be predisposed to glaucoma. Cautious prescribing is also indicated in patients predisposed to obstructive disease of the gastro-intestinal tract and those with urinary symptoms associated with prostatic hypertrophy.
In a proportion of patients undergoing neuroleptic treatment, tardive dyskinesias will occur. While anticholinergic agents do not cause this syndrome, when given in combination with neuroleptics they may exacerbate the symptoms of tardive dyskinesia or reduce the threshold at which these symptoms appear in predisposed patients.
In such individuals subsequent adjustment of neuroleptic therapy or reduction in anticholinergic treatment should be considered. Patients with mental disorders occasionally experience a precipitation of a psychotic episode when procyclidine is administered for the treatment of the extrapyramidal side effects of neuroleptics.
8). Specifically, the elderly patients may be particularly vulnerable to Central Nervous System (CNS) disturbances such as confusion, impairment of cognitive function and memory, disorientation and hallucinations. These effects are usually reversible on reduction or discontinuation of anticholinergic therapy.
There is no specific information available concerning the use of procyclidine in patients with impaired renal or hepatic function. However, since procyclidine is metabolised in the liver and excreted via urine care should be exercised when administering procyclidine to patients with impaired renal or hepatic function.
Procyclidine should not be withdrawn abruptly as rebound parkinsonian symptoms may occur. Procyclidine, along with other anticholinergic drugs, has the potential to be abused. Although the cases of abuse are rare, physicians should exercise caution in prescribing procyclidine to patients with symptoms that may not be genuine.
Procyclidine hydrochloride tablets contains lactose Patients with rare hereditary problems of galactose intolerance, the total lactase deficiency or glucose-galactose malabsorption should not take this medicine. Procyclidine hydrochloride tablets contains sodium This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‘sodium-free’.

This is not medical advice. Consult a qualified healthcare professional.

Overview

Regulatory status by market

GBUnited Kingdom· MHRA

Drug interactions

Drugs in the same class

Sources & citations