Primidone
Barbiturates and Derivatives
Sold as ENODAMA
- Drug class
- Barbiturates and Derivatives
- Availability
- Prescription only
- Routes
- Oral
- Markets covered
- 3
- Products on record
- 45
- FDA reports (12 mo)
- 481
Overview
Plain-language summary, compiled from the cited regulatory records
Primidone is a medication classified as a barbiturate and derivative [1]. It is approved for use in managing certain types of epileptic seizures, including grand mal, psychomotor, and focal seizures [1]. Primidone can be used as a standalone treatment or in combination with other anticonvulsant medications [1]. It may also be effective in controlling grand mal seizures that have not responded to other anticonvulsant therapies [1].
In the past 12 months, there have been 481 adverse event reports associated with primidone [2]. The most frequently reported adverse events include off-label use, reports of the drug being ineffective, drug interactions, diarrhea, and fatigue [2].
This is not medical advice. Consult a qualified healthcare professional.
Regulatory status by market
| Market | Regulator | Products | Last revision |
|---|---|---|---|
| GB United Kingdom | MHRA | 40 | April 10, 2026 |
| US United States | FDA | 3 | June 10, 2025 |
| CA Canada | Health Canada | 2 | November 17, 2025 |
GBUnited Kingdom· MHRA
40 products
Uses
'Primidone' is indicated in the management of grand mal and psychomotor (temporal lobe) epilepsy. It is also of value in the management of focal or Jacksonian seizures, myoclonic jerks and akinetic attacks. Management of essential tremor.
How to take
USUnited States· FDA
3 products
Uses
INDICATIONS AND USAGE
Primidone, used alone or concomitantly with other anticonvulsants, is indicated in the control of grand mal, psychomotor, and focal epileptic seizures. It may control grand mal seizures refractory to other anticonvulsant therapy.
How to take
CACanada· Health Canada
2 products
2 products on record with this regulator. Detailed label text (uses, dosage, side effects) is being ingested — the original document is linked under Sources [3].
Drug interactions
Known interactions involving Primidone. Select one for details. This list is informational and not a complete interaction checker.
Showing 240 of 600. Type above to find a specific drug.
Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.
Sources & citations
- [1]MHRA (UK) · PL140400038 · revised January 3, 2025
- [2]FDA DailyMed · 0193c0a4-f593-60… · revised June 10, 2025 [PDF]
- [3]Health Canada (DPD) · 00396761 · revised November 17, 2025
- [4]OpenFDA adverse-event reports (US), 12 months ending June 4, 2026.
Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.