The onset of action of Veltassa occurs 4 – 7 hours after administration. 4). Posology Veltassa is administrated once daily. The recommended starting dose of Veltassa varies with age. Multiple sachets may be used to achieve the desired dose.
The daily dose may be adjusted in intervals of one week or longer, based on the serum potassium level and the desired target range. 4). The duration of treatment should be individualized by the treating physician based on the need of serum potassium management.
If serum potassium falls below the desired range, the dose should be reduced or discontinued. 5). 4 g patiromer once daily. 2 g daily. Adolescents aged 12 to 17 years The recommended starting dose is 4 g patiromer once daily. 2 g daily.
4 g patiromer sachets if doses above 7 g are needed. Missed doses If a dose is missed, the missed dose should be taken as soon as possible on the same day. The missed dose should not be taken with the next dose. Special populations Elderly No special dose and administration guidelines are recommended for this population.
Patients on dialysis There is limited data on the use of patiromer in patients on dialysis. No special dose and administration guidelines were applied to these patients in clinical trials. No paediatric patients receiving dialysis have been treated with patiromer.
73 m². Paediatric population The safety and efficacy of patiromer in children aged under 12 years have not yet been established. The data in adolescents aged 12 to 17 years are limited to 6 months exposure. 4). Method of administration Oral use.
Veltassa should be mixed with water and stirred to a suspension of uniform consistency. The recommended total volumes for preparation of the suspension are dose dependent: • 1 g patiromer: 10 mL • 2 g patiromer: 20 mL • 3 g patiromer: 30 mL • 4 g patiromer: 40 mL • >4 g patiromer: 80 mL The suspension should be prepared according to the following steps: • The first half of the recommended volume for the required dose should be poured into a glass and the complete dose of patiromer should be added, then stirred.
• The second half of the recommended volume should be added and the suspension stirred again thoroughly. 4 The powder will not dissolve. More water may be added to the mixture as needed for desired consistency. However, larger volumes might lead to an accelerated sedimentation of the powder.
The mixture should be taken within 1 hour of initial suspension. If powder remains in the glass after drinking, more water should be added and the suspension stirred and taken immediately. This may be repeated as needed to ensure the entire dose is administered.
According to personal preferences, following liquids or soft foods can be used instead of water to prepare the mixture by following the same steps as described above: apple juice, cranberry juice, pineapple juice, orange juice, grape juice, pear juice, apricot nectar, peach nectar, yoghurt, milk, thickener (for example: cornstarch), apple sauce, vanilla and chocolate pudding.
The potassium content of liquids or soft foods used to prepare the mixture should be considered as part of the dietary recommendations on potassium intake for each individual patient. In general, cranberry juice intake should be limited to moderate amounts (for example less than 400 mL per day) due to its potential interaction with other medicinal products.
This medicine can be taken with or without meals. g. microwaved) or added to heated foods or liquids. It should not be taken in its dry form. 4 g patiromer, the suspension should be prepared as described above in the section relating to the oral administration.
2 g patiromer a total volume of 240 mL. These volumes ensure that the suspension readily flows through the tubes. Compatibility has been shown with tubes made from polyurethane, silicone, and polyvinyl chloride. 5 Fr) or larger. After administration the tube should be flushed with water.
6.