Orphenadrine: Uses, Side Effects, Dosage - Drugvu

ℹ️ Compiled from public regulatory records · Last regulator revision: March 6, 2026🚩 Report this page

Orphenadrine

Active ingredient

US FDAGB MHRA

Drug class: -
Availability: Prescription only
Routes: Oral
Markets covered: 2
Products on record: 2

Overview

Orphenadrine is an active pharmaceutical ingredient. The information below is compiled per regulator from the product labels on record, with direct links to the original documents.

Regulatory status by market

Market	Regulator	Products	Last revision
US United States	FDA	1	January 1, 2026
GB United Kingdom	MHRA	1	March 6, 2026

USUnited States· FDA

1 product

Uses

USOfficial regulatory label· revised January 1, 2026[1]

INDICATIONS AND USAGE
Orphenadrine citrate extended-release tablets are indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions.

How to take

GBUnited Kingdom· MHRA

1 product

Uses

GBOfficial regulatory label· revised March 6, 2026[2]

Anticholinergic, for the treatment of all forms of Parkinsonism, including drug induced (neuroleptic syndrome).

How to take

Drug interactions

Known interactions involving Orphenadrine. Select one for details. This list is informational and not a complete interaction checker.

Alfentanil Benzhydrocodone Buprenorphine Butorphanol Codeine Dezocine Dihydrocodeine Fentanyl Hydrocodone Hydromorphone Levorphanol Meperidine Methadone Morphine Nalbuphine Oliceridine Oxycodone Oxymorphone Pentazocine Potassium Chloride Potassium Citrate Propoxyphene Remifentanil Sufentanil Tapentadol Topiramate Tramadol Zonisamide Acebutolol Acetylcholine Aclidinium Acrivastine Aldesleukin Alfuzosin Alprazolam Amantadine Amiloride Amitriptyline Amobarbital Amoxapine Amyl Nitrite Apomorphine Apraclonidine Aripiprazole Asenapine Atenolol Atropine Azatadine Azelastine Azilsartan Baclofen Benazepril Bepridil Betaxolol Biperiden Bisoprolol Botulinum Toxin Type A Botulinum Toxin Type B Brexanolone Brexpiprazole Brimonidine Brivaracetam Bromocriptine Brompheniramine Bumetanide Bupropion Buspirone Butabarbital Butalbital Cannabidiol Captopril Carbamazepine Carbamoylcholine Carbinoxamine Cariprazine Carisoprodol Carteolol Carvedilol Cenobamate Cetirizine Chlorcyclizine Chlordiazepoxide Chlormezanone Chlorpheniramine Chlorpromazine Citalopram Clemastine Clevidipine Clidinium Clobazam Clomipramine Clonazepam Clonidine Clorazepate Clozapine Cyclizine Cyclobenzaprine Cyproheptadine Darifenacin Demecarium Deserpidine Desipramine Desvenlafaxine Deutetrabenazine Dexbrompheniramine Dexmedetomidine Dextromethorphan Diazepam Diazoxide Dicyclomine Diltiazem Dimenhydrinate Diphenhydramine Disopyramide Donepezil Doxazosin Doxepin Doxylamine Dronabinol Droperidol Duloxetine Eluxadoline Enalapril Entacapone Eplerenone Eprosartan Escitalopram Esketamine Eslicarbazepine Esmolol Estazolam Eszopiclone Ethacrynate Ethanol Ethosuximide Ethotoin Ezogabine Felbamate Fenoldopam Fesoterodine Flavoxate Flibanserin Fluoxetine Fluphenazine Flurazepam Fluvoxamine Fosinopril Fosphenytoin Furosemide Gabapentin Galantamine Glycopyrronium Guanabenz Guanadrel Guanethidine Guanfacine Halazepam Haloperidol Hydralazine Hydroxyzine Hyoscyamine Ifosfamide Iloperidone Imipramine Ipratropium Irbesartan Isocarboxazid Isoflurophate Isosorbide Dinitrate Ketamine Labetalol Lamotrigine Lasmiditan Lemborexant Levamlodipine Levetiracetam Levocetirizine Lisinopril Lithium Carbonate Lofexidine Loperamide Lorazepam Losartan Loxapine Lumateperone Lurasidone Maprotiline Meclizine Memantine Mepenzolate Mephenytoin Mephobarbital Meprobamate Mesoridazine Methdilazine Methotrimeprazine Methscopolamine Methsuximide Metoclopramide Metoprolol Metyrosine Midazolam Minoxidil Mirtazapine Moexipril Molindone Nabilone Nadolol Nebivolol Nefazodone Nimodipine Nitroglycerin Nitroprusside Nortriptyline Olanzapine Olmesartan Olopatadine Opicapone Opium Oxazepam Oxcarbazepine Oxybutynin Paliperidone Paraldehyde Paramethadione Paroxetine Penbutolol Pentobarbital Perampanel Pergolide Perindopril Perphenazine Phenacemide Phenelzine Phenindamine Phenobarbital Phenoxybenzamine Phensuximide Phentolamine Phenylephrine

Showing 240 of 399. Type above to find a specific drug.

Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.

Sources & citations

[1]FDA DailyMed · 106be130-b4f8-5c… · revised January 1, 2026 [PDF]
[2]MHRA (UK) · PL004270076 · revised March 6, 2026

Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.

Side effects & warnings

GBOfficial regulatory label· Adverse reactions· revised March 6, 2026[2]

System Organ Class Common >1/100 <1/10 Uncommon >1/1000 <1/100 Rare >1/10,000 <1/1000 Immune system disorder Hypersensitivity Nervous system disorder Dizziness, restlessness Sedation, confusion, nervousness, hallucinations, convulsions, insomnia, euphoria, co-ordination disturbances, light-headedness Memory disturbances Eye disorders Accommodation disorders Cardiac disorders Tachycardia Gastrointestinal disorders Dry mouth, nausea, gastrointestinal disturbances Constipation Renal and urinary disorders Urinary retention

GBOfficial regulatory label· Warnings and precautions· revised March 6, 2026[2]

2). When used alone or with analgesics, pain or skeletal muscle spasms have been reported. Use with caution in conditions characterised by tachycardia. g. in heart failure, thyrotoxicosis) as they may cause further acceleration of the heart rate.
Anti-muscarinic agents such as orphenadrine are not effective in the treatment of tardive dyskinesia which may be made worse and should not be used in patients with this condition. Care should be taken when using in patients with concomitant hypertension, cardiac, renal or hepatic dysfunction.
Use with caution in patients with micturition difficulties and in pregnancy and breastfeeding. Avoid abrupt discontinuation of treatment. For some patients orphenadrine may be a drug of abuse. May cause allergic reactions (possibly delayed).
Liquid Maltitol (E965) 2049mg in each 5ml. Patients with rare hereditary problems of fructose intolerance should not take this medicine. May have a mild laxative effect. 7 kcal/5ml • Benzyl Alcohol. 03mg of benzyl alcohol in each 5 ml.
Benzyl alcohol may cause allergic reactions. High volumes should be used with caution and only if necessary, especially in subjects with liver or kidney impairment because of the risk of accumulation and toxicity (metabolic acidosis).
7mg in each 5ml. The additive effect of concomitantly administered products containing sorbitol (or fructose) and dietary intake of sorbitol (or fructose) should be taken into account. The content of sorbitol in medicinal products for oral use may affect the bioavailability of other medicinal products for oral use administered concomitantly.
Patients with hereditary fructose intolerance (HFI) should not take/be given this medicinal product. 7mg in each 5 ml. The amount in 5 ml of this medicine is equivalent to less than 1 ml beer or 1 ml wine. The small amount of alcohol in this medicine will not have any noticeable effects.
• This medicine contains less than 1 mmol Sodium (23 mg) per 5ml, that is to say essentially ‘sodium-free’.

This is not medical advice. Consult a qualified healthcare professional.