Nitrofurantoin

For the treatment of and prophylaxis against acute or recurrent, uncomplicated lower urinary tract infections or pyelitis either spontaneous or following surgical procedures. It is indicated in adults, children and infants over 3 months old.

Nitrofurantoin is specifically indicated for the treatment of infections when due to susceptible strains of Escherichia coli, Enterococci, Staphylococci, Citrobacter, Klebsiella and Enterobacter.

1 INDICATIONS & USAGE Nitrofurantoin is indicated in adults and pediatric patients 1 month of age and older for the treatment of urinary tract infections due to susceptible strains of Escherichia coli , Enterococcus species, Staphylococcus aureus , Klebsiella species and Enterobacter species.

7)]. Usage To reduce the development of drug-resistant bacteria and maintain the effectiveness of nitrofurantoin and other antibacterial drugs, nitrofurantoin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Nitrofurantoin is a nitrofuran antibacterial indicated in adults and pediatric patients 1 month of age and older for the treatment of urinary tract infections caused by susceptible bacteria. (1) Limitations of Use Nitrofurantoin is not indicated for the treatment of pyelonephritis or perinephric abscesses.

Adults and Children over 12 years:

One JAMP Nitrofurantoin BID 100 mg capsule twice a day for 7 days (maximum 200 mg/day). JAMP Nitrofurantoin BID should be taken every 12 hours with food or milk to minimize gastric upset. Therapy for acute urinary tract infections should be continued for 7 days or for at least 3 days after sterility of the urine is obtained.

Continued infection indicates the need for re-evaluation. 18 g/mol Description Nitrofurantoin is a yellow crystalline powder or yellow crystals; very slightly soluble in water and in ethanol (96 percent), soluble in dimethylformamide.

JAMP Nitrofurantoin BID (Nitrofurantoin Capsules) Product Monograph Page 11 of 20 Composition Each 100 mg JAMP Nitrofurantoin BID capsule contains the equivalent of 100 mg of nitrofurantoin in the form of nitrofurantoin macrocrystals and nitrofurantoin monohydrate and the following inactive ingredients: carbomer homopolymer type B, lactose monohydrate, magnesium stearate, starch – maize, povidone and talc.