ℹ️ Compiled from public regulatory records · Last regulator revision: April 14, 2026

Metyrosine

Tyrosine Hydroxylase Inhibitors

US FDA

Drug class: Tyrosine Hydroxylase Inhibitors
Availability: Prescription only
Routes: Oral
Markets covered: 1
Products on record: 1
FDA reports (12 mo): 10

C02KBTyrosine Hydroxylase Inhibitors

Overview

Plain-language summary, compiled from the cited regulatory records

Metyrosine is a medication classified as a tyrosine hydroxylase inhibitor [1]. It is approved for the treatment of patients diagnosed with pheochromocytoma [1]. Specifically, it is used to prepare patients for surgery, to manage cases where surgery is not an option, and for the ongoing treatment of malignant pheochromocytoma [1]. Metyrosine is not recommended for managing general high blood pressure [1].

This medication is available under various brand names [1]. In the past 12 months, there have been 10 adverse event reports associated with this active ingredient [2]. The most frequently reported adverse events include malignant neoplasm, off-label use, pyrexia, acute myocardial infarction, and adrenal hemorrhage [2].

This is not medical advice. Consult a qualified healthcare professional.

Regulatory status by market

Market	Regulator	Products	Last revision
US United States	FDA	1	April 14, 2026

USUnited States· FDA

1 product

Uses

USOfficial regulatory label· revised April 14, 2026[1]

INDICATIONS AND USAGE
Metyrosine capsules are indicated in the treatment of patients with pheochromocytoma for: 1. Preoperative preparation of patients for surgery. 2. Management of patients when surgery is contraindicated. 3. Chronic treatment of patients with malignant pheochromocytoma.
Metyrosine capsules are not recommended for the control of essential hypertension.

How to take

Drug interactions

Known interactions involving Metyrosine. Select one for details. This list is informational and not a complete interaction checker.

Alfentanil Alprazolam Amifostine Amisulpride Amitriptyline Amobarbital Amoxapine Aripiprazole Azatadine Azelastine Baclofen Benzhydrocodone Biperiden Brexanolone Brexpiprazole Brivaracetam Bromocriptine Brompheniramine Buprenorphine Buspirone Butabarbital Butalbital Butorphanol Canagliflozin Cannabidiol Carbamazepine Carbinoxamine Cariprazine Carisoprodol Cenobamate Chlordiazepoxide Chlormezanone Chlorphenesin Chlorpheniramine Chlorpromazine Chlorzoxazone Citalopram Clemastine Clobazam Clomipramine Clonazepam Clonidine Clorazepate Codeine Cyclizine Cyclobenzaprine Cyproheptadine Dantrolene Dapagliflozin Desipramine Desvenlafaxine Deutetrabenazine Dexbrompheniramine Dexmedetomidine Dextromethorphan Dezocine Diazepam Dichloralphenazone Difenoxin Dihydrocodeine Dimenhydrinate Diphenhydramine Diphenoxylate Doxepin Doxylamine Dronabinol Droperidol Duloxetine Empagliflozin Entacapone Ertugliflozin Escitalopram Eslicarbazepine Estazolam Eszopiclone Ethanol Ethchlorvynol Ethosuximide Ethotoin Ezogabine Felbamate Fenoldopam Fentanyl Flavoxate Fluoxetine Fluphenazine Flurazepam Fluvoxamine Fosphenytoin Gabapentin Guanfacine Halazepam Haloperidol Hydrocodone Hydromorphone Hydroxyzine Iloperidone Imipramine Isocarboxazid Ketamine Lamotrigine Lasmiditan Lemborexant Levetiracetam Levorphanol Licorice Lithium Carbonate Lofexidine Lorazepam Lumateperone Lurasidone Maprotiline Meclizine Meperidine Mephenytoin Mephobarbital Meprobamate Mesoridazine Metaxalone Methadone Methdilazine Methocarbamol Methotrimeprazine Methsuximide Metoclopramide Midazolam Mirtazapine Molindone Morphine Nabilone Nalbuphine Nefazodone Nortriptyline Oliceridine Opicapone Opium Orphenadrine Oxazepam Oxcarbazepine Oxycodone Oxymorphone Paraldehyde Paramethadione Paroxetine Pentazocine Pentobarbital Pentoxifylline Perampanel Pergolide Perphenazine Phenacemide Phenelzine Phenindamine Phenobarbital Phensuximide Phenyltoloxamine Phenytoin Pramipexole Pregabalin Primidone Prochlorperazine Procyclidine Promazine Promethazine Propiomazine Protriptyline Pyrilamine Quazepam Ramelteon Rasagiline Remifentanil Remimazolam Riociguat Ropinirole Rotigotine Rufinamide Secobarbital Sertraline Sibutramine Stiripentol Sufentanil Suvorexant Tapentadol Tasimelteon Temazepam Tetrabenazine Thalidomide Thiethylperazine Thiopental Thioridazine Thiothixene Tiagabine Tizanidine Tolcapone Topiramate Tramadol Tranylcypromine Trazodone Triazolam Trifluoperazine Triflupromazine Trihexyphenidyl Trimeprazine Trimethadione Trimethobenzamide Trimipramine Tripelennamine Triprolidine Valbenazine Valproate Venlafaxine Verteporfin Vigabatrin Zaleplon Ziconotide Zolpidem Zonisamide

Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.

Sources & citations

[1]FDA DailyMed · 027f02b1-be49-48… · revised April 14, 2026 [PDF]
[2]OpenFDA adverse-event reports (US), 12 months ending June 4, 2026.

Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.