Metaxalone: Uses, Side Effects, Dosage - Drugvu

ℹ️ Compiled from public regulatory records · Last regulator revision: January 20, 2025🚩 Report this page

Metaxalone

Active ingredient

US FDA

Drug class: -
Availability: Prescription only
Routes: Oral
Markets covered: 1
Products on record: 4
FDA reports (12 mo): 92

Overview

Metaxalone is an active pharmaceutical ingredient. The information below is compiled per regulator from the product labels on record, with direct links to the original documents.

Regulatory status by market

Market	Regulator	Products	Last revision
US United States	FDA	4	January 20, 2025

USUnited States· FDA

4 products

Uses

USOfficial regulatory label· revised July 25, 2022[1]

INDICATIONS AND USAGE
Metaxalone is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties.
Metaxalone does not directly relax tense skeletal muscles in man.

How to take

Drug interactions

Known interactions involving Metaxalone. Select one for details. This list is informational and not a complete interaction checker.

Alfentanil Buprenorphine Butorphanol Codeine Dezocine Dihydrocodeine Fentanyl Hydrocodone Hydromorphone Leflunomide Lomitapide Meperidine Methadone Mipomersen Morphine Nalbuphine Oxycodone Pentazocine Propoxyphene Remifentanil Sufentanil Tapentadol Teriflunomide Tramadol Acebutolol Aldesleukin Alfuzosin Alprazolam Amitriptyline Amobarbital Amoxapine Apomorphine Apraclonidine Aripiprazole Asenapine Asparaginase Atenolol Azatadine Azilsartan Baclofen Bedaquiline Bepridil Betaxolol Biperiden Bisoprolol Botulinum Toxin Type A Botulinum Toxin Type B Brentuximab Vedotin Brexpiprazole Brimonidine Brivaracetam Bromocriptine Brompheniramine Buspirone Butabarbital Butalbital Cannabidiol Carbamazepine Carbinoxamine Cariprazine Carisoprodol Carteolol Carvedilol Cetirizine Chlordiazepoxide Chlormezanone Chlorpheniramine Chlorpromazine Citalopram Clemastine Clevidipine Clobazam Clofarabine Clomipramine Clonazepam Clonidine Clorazepate Clozapine Cyclizine Cyproheptadine Dantrolene Deserpidine Desipramine Desvenlafaxine Dexbrompheniramine Dexmedetomidine Dextromethorphan Diazepam Diphenhydramine Doxazosin Doxepin Doxylamine Dronabinol Droperidol Duloxetine Efavirenz Entacapone Eplerenone Escitalopram Esketamine Eslicarbazepine Esmolol Estazolam Eszopiclone Ethacrynate Ethanol Ethosuximide Ethotoin Ezogabine Felbamate Flavoxate Flibanserin Fluoxetine Fluphenazine Flurazepam Fluvoxamine Gabapentin Halazepam Haloperidol Hydroxyzine Idelalisib Ifosfamide Iloperidone Imipramine Interferon Beta-1a Interferon Beta-1b Isocarboxazid Ketamine Labetalol Lamotrigine Levetiracetam Levocetirizine Lofexidine Lorazepam Loxapine Lurasidone Maprotiline Mephenytoin Mephobarbital Meprobamate Mesoridazine Methocarbamol Methotrexate Methsuximide Metoclopramide Metoprolol Metyrosine Midazolam Mirtazapine Molindone Nabilone Nadolol Naltrexone Nebivolol Nefazodone Nimodipine Nortriptyline Olanzapine Olopatadine Opicapone Opium Oxazepam Oxcarbazepine Paliperidone Paraldehyde Paramethadione Paroxetine Pegaspargase Peginterferon Beta-1a Penbutolol Pentobarbital Perampanel Pergolide Perphenazine Phenacemide Phenelzine Phenobarbital Phensuximide Phenytoin Pimozide Pindolol Pramipexole Pregabalin Primidone Prochlorperazine Procyclidine Promazine Promethazine Propiomazine Propranolol Protriptyline Pyrilamine Quazepam Quetiapine Ramelteon Rasagiline Remimazolam Reserpine Risperidone Ropinirole Rotigotine Rufinamide Secobarbital Sertraline Sibutramine Silodosin Sotalol Stiripentol Suvorexant Tamsulosin Tasimelteon Telmisartan Temazepam Tetrabenazine Thalidomide Thioguanine Thiopental Thioridazine Thiothixene Tiagabine Tizanidine Tolcapone Topiramate Trabectedin Tranylcypromine Trazodone Triazolam Trichlormethiazide Trifluoperazine Triflupromazine Trihexyphenidyl Trimeprazine Trimethadione Trimethobenzamide Trimipramine Tripelennamine Triprolidine Valbenazine Valproate Venlafaxine

Showing 240 of 246. Type above to find a specific drug.

Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.

Sources & citations

[1]FDA DailyMed · 02c42f72-5d78-43… · revised July 25, 2022 [PDF]
[2]OpenFDA adverse-event reports (US), 12 months ending June 4, 2026.

Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.

Side effects & warnings

USOfficial regulatory label· Adverse reactions· revised July 25, 2022[1]

ADVERSE REACTIONS
The most frequent reactions to metaxalone include:
CNS : drowsiness, dizziness, headache, and nervousness or “irritability”; Digestive : nausea, vomiting, gastrointestinal upset.
Other adverse reactions are:
Immune System : anaphylaxis, hypersensitivity reaction, rash with or without pruritus; Hematologic : leukopenia; hemolytic anemia; Hepatobiliary : jaundice; CNS : cases of serotonin syndrome, a potentially life-threatening condition, have been reported during concomitant use of serotonergic drugs with metaxalone used within the recommended dosage range and with metaxalone as a single agent taken at doses higher than the recommended dose (see WARNINGS , PRECAUTIONS: Drug Interactions , and OVERDOSAGE ).

USOfficial regulatory label· Warnings and precautions· revised July 25, 2022[1]

WARNINGS
Serotonin Syndrome Cases of serotonin syndrome, a potentially life-threatening condition, have been reported during concomitant use of serotonergic drugs with Metaxalone used within the recommended dosage range (see PRECAUTIONS: Drug Interactions ) and with Metaxalone as a single agent taken at doses higher than the recommended dose (see OVERDOSAGE ).
, mirtazapine, trazodone, tramadol), and drugs that impair metabolism of serotonin (including monoamine oxidase (MAO) inhibitors, both those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue) (see PRECAUTIONS: Drug Interactions ).
, nausea, vomiting, diarrhea). The onset of symptoms generally occurs within several hours to a few days, but may occur later than that. Discontinue Metaxalone if serotonin syndrome is suspected. , alcohol, benzodiazepines, opioids, tricyclic antidepressants (TCAs)) may be additive.
Exercise caution with patients who take more than one of these CNS depressants simultaneously. Follow patients closely for signs and symptoms of respiratory depression and sedation (see PRECAUTIONS: Drug Interactions ).

This is not medical advice. Consult a qualified healthcare professional.