Meprobamate: Uses, Side Effects, Dosage - Drugvu

ℹ️ Compiled from public regulatory records · Last regulator revision: June 19, 2021🚩 Report this page

Meprobamate

Carbamates

US FDA

Drug class: Carbamates
Availability: Prescription only
Routes: Oral
Markets covered: 1
Products on record: 1
FDA reports (12 mo): 4

Overview

Meprobamate is an active pharmaceutical ingredient in the Carbamates group (N05BC). The information below is compiled per regulator from the product labels on record, with direct links to the original documents.

Regulatory status by market

Market	Regulator	Products	Last revision
US United States	FDA	1	June 19, 2021

USUnited States· FDA

1 product

Uses

USOfficial regulatory label· revised June 19, 2021[1]

INDICATIONS AND USAGE
Anxiety or tension associated with the stress of everyday life usually do not require treatment with an anxiolytic. The effectiveness of meprobamate tablets in long-term use, that is,more than 4 months, has not been assessed by systematic clinical studies.
The physician should periodically reassess the usefulness of the drug for the individual patient.

How to take

Drug interactions

Known interactions involving Meprobamate. Select one for details. This list is informational and not a complete interaction checker.

Alfentanil Benzhydrocodone Buprenorphine Butorphanol Codeine Dezocine Dihydrocodeine Fentanyl Hydrocodone Hydromorphone Levorphanol Meperidine Methadone Morphine Nalbuphine Oliceridine Oxycodone Oxymorphone Pentazocine Propoxyphene Remifentanil Sufentanil Tapentadol Tramadol Acebutolol Aldesleukin Alfuzosin Amiloride Amitriptyline Amobarbital Amoxapine Amyl Nitrite Apomorphine Apraclonidine Aripiprazole Asenapine Atenolol Azatadine Azelastine Azilsartan Baclofen Benazepril Bendroflumethiazide Benzthiazide Bepridil Betaxolol Biperiden Bisoprolol Brexanolone Brexpiprazole Brimonidine Brivaracetam Bromocriptine Brompheniramine Bumetanide Bupropion Buspirone Cannabidiol Captopril Carbamazepine Carbinoxamine Cariprazine Carisoprodol Carteolol Carvedilol Cenobamate Cetirizine Chlordiazepoxide Chlorothiazide Chlorphenesin Chlorpheniramine Chlorpromazine Chlorthalidone Chlorzoxazone Citalopram Clemastine Clevidipine Clobazam Clomipramine Clonidine Clorazepate Clozapine Cyclobenzaprine Cyproheptadine Dantrolene Deserpidine Desipramine Desvenlafaxine Deutetrabenazine Dexbrompheniramine Dexmedetomidine Dextromethorphan Diazoxide Diltiazem Diphenhydramine Doxazosin Doxepin Doxylamine Dronabinol Droperidol Duloxetine Enalapril Entacapone Eplerenone Eprosartan Escitalopram Esketamine Eslicarbazepine Esmolol Estazolam Eszopiclone Ethacrynate Ethanol Ethosuximide Ethotoin Ezogabine Felbamate Fenoldopam Flavoxate Flibanserin Fluoxetine Fluphenazine Flurazepam Fluvoxamine Fosinopril Fosphenytoin Fospropofol Furosemide Gabapentin Guanabenz Guanadrel Guanethidine Guanfacine Halazepam Haloperidol Hydralazine Hydrochlorothiazide Hydroflumethiazide Ifosfamide Iloperidone Imipramine Indapamide Irbesartan Isocarboxazid Isosorbide Dinitrate Ketamine Labetalol Lamotrigine Lasmiditan Lemborexant Levamlodipine Levetiracetam Levocetirizine Lisinopril Lithium Carbonate Lofexidine Losartan Loxapine Lumateperone Lurasidone Maprotiline Meclizine Mephenytoin Mesoridazine Metaxalone Methdilazine Methocarbamol Methsuximide Metoclopramide Metolazone Metoprolol Metyrosine Minoxidil Mirtazapine Moexipril Molindone Nabilone Nadolol Nebivolol Nefazodone Nimodipine Nitroglycerin Nitroprusside Nortriptyline Olanzapine Olmesartan Olopatadine Opicapone Opium Orphenadrine Oxcarbazepine Paliperidone Paraldehyde Paramethadione Paroxetine Penbutolol Pentobarbital Perampanel Pergolide Perindopril Perphenazine Phenacemide Phenelzine Phenindamine Phenobarbital Phenoxybenzamine Phensuximide Phentolamine Phenyltoloxamine Phenytoin Pimozide Pindolol Polythiazide Pramipexole Prazosin Pregabalin Primidone Prochlorperazine Procyclidine Promazine Promethazine Propiomazine Propofol Propranolol Protriptyline Pyrilamine Quazepam Quetiapine Quinapril Ramelteon Ramipril Rasagiline Reserpine Risperidone Ropinirole Rotigotine Rufinamide Secobarbital Sertraline Sibutramine

Showing 240 of 325. Type above to find a specific drug.

Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.

Sources & citations

[1]FDA DailyMed · 17d814e2-b277-4d… · revised June 19, 2021 [PDF]
[2]OpenFDA adverse-event reports (US), 12 months ending June 4, 2026.

Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.

Side effects & warnings

USOfficial regulatory label· Adverse reactions· revised June 19, 2021[1]

ADVERSE REACTIONS
Central Nervous System Drowsiness, ataxia, dizziness, slurred speech, headache, vertigo,weakness, paresthesias, impairment of visual accommodation,euphoria, overstimulation, paradoxical excitement, fast EEG activity. Gastrointestinal Nausea, vomiting, diarrhea.
Cardiovascular Palpitation, tachycardia, various forms of arrhythmia, transient ECG changes, syncope; also hypotensive crisis (including one fatal case). Allergic or Idiosyncratic Allergic or idiosyncratic reactions are usually seen within the period of the first to fourth dose in patients having had no previous contact with the drug.
Milder reactions are characterized by an itchy, urticarial, or erythematous maculopapular rash which may be generalized or confined to the groin. Other reactions have included leukopenia, acute nonthrombocytopenic purpura, petechiae, ecchymoses, eosinophilia,peripheral edema, adenopathy, fever, fixed drug eruption with cross reaction to carisoprodol, and cross sensitivity between meprobamate/mebutamate and meprobamate/carbromal.
More severe hypersensitivity reactions, rarely reported, include hyperpyrexia, chills, angioneurotic edema, bronchospasm, oliguria and anuria. Also, anaphylaxis, erythema multiforme, exfoliative dermatitis, stomatitis, proctitis, Stevens-Johnson syndrome and bullous dermatitis, including one fatal case of the latter following administration of meprobamate in combination with prednisolone.
In case of allergic or idiosyncratic reactions to meprobamate,discontinue the drug and initiate appropriate symptomatic therapy,which may include epinephrine, antihistamines, and in severe cases,corticosteroids. In evaluating possible allergic reactions, also consider allergy to excipients.
Hematologic (See also Allergic or Idiosyncratic ). Agranulocytosis and aplastic anemia have been reported. These cases rarely were fatal. Rare cases of thrombocytopenic purpura have been reported. Other Exacerbation of porphyric symptoms.

USOfficial regulatory label· Warnings and precautions· revised June 19, 2021[1]

WARNINGS
Drug Dependence Physical dependence, psychological dependence, and abuse have occurred. When chronic intoxication from prolonged use occurs, it usually involves ingestion of greater than recommended doses and is manifested by ataxia, slurred speech, and vertigo.
Therefore, careful supervision of dose and amounts prescribed is advised, as well as avoidance of prolonged administration, especially for alcoholics and other patients with a known propensity for taking excessive quantities of drugs.
Sudden withdrawal of the drug after prolonged and excessive use may precipitate recurrence of pre-existing symptoms such as anxiety,anorexia, insomnia, or withdrawal reactions such as vomiting, ataxia,tremors, muscle twitching, confusional states, hallucinosis, and rarely, convulsive seizures.
Such seizures are more likely to occur in persons with central nervous system damage or pre-existent or latent convulsive disorders. Onset of withdrawal symptoms occurs usually within 12 to 48 hours after discontinuation of meprobamate;symptoms usually cease within the next 12 to 48 hours.
When excessive dosage has continued for weeks or months, dosage should be reduced gradually over a period of one or two weeks rather than abruptly stopped. Alternatively, a long-acting barbiturate may be substituted, then gradually withdrawn.
Potentially Hazardous Tasks Patients should be warned that meprobamate may impair the mental and/or physical abilities required for performance of potentially hazardous tasks such as driving or operating machinery. Additive Effects Since the effects of meprobamate and alcohol or meprobamate and other CNS depressants or psychotropic drugs may be additive,appropriate caution should be exercised with patients who take more than one of these agents simultaneously.
Usage in Pregnancy and Lactation An increased risk of congenital malformations associated with the use of minor tranquilizers (meprobamate, chlordiazepoxide and diazepam) during the first trimester of pregnancy has been suggested in several studies.
Because use of these drugs is rarely a matter of urgency, their use during this period should almost always be avoided. The possibility that a woman of childbearing potential may be pregnant at the time of institution of therapy should be considered.

This is not medical advice. Consult a qualified healthcare professional.