Isoniazid
Hydrazides
Sold as ISOTAMINE · ISOTAMINE B 300
- Drug class
- Hydrazides
- Availability
- Prescription only
- Routes
- Oral
- Markets covered
- 3
- Products on record
- 20
- FDA reports (12 mo)
- 773
Overview
Plain-language summary, compiled from the cited regulatory records
Isoniazid is a medication belonging to the drug class of hydrazides [1]. It is approved for the treatment of all forms of tuberculosis where the causative organisms are susceptible to the drug [1]. However, it is crucial that active tuberculosis is treated with multiple anti-tuberculosis medications simultaneously to prevent the development of drug resistance [1]. Isoniazid is also recommended for preventive therapy in specific groups, irrespective of age [1].
Isoniazid is available in the market under various brand names [1]. In the past 12 months, there have been 773 adverse event reports associated with this active ingredient [2]. The most frequently reported adverse events include drug ineffectiveness, off-label use, nausea, drug interaction, and arthralgia [2].
This is not medical advice. Consult a qualified healthcare professional.
Regulatory status by market
| Market | Regulator | Products | Last revision |
|---|---|---|---|
| GB United Kingdom | MHRA | 12 | May 29, 2026 |
| US United States | FDA | 1 | February 16, 2026 |
| CA Canada | Health Canada | 7 | March 22, 2025 |
GBUnited Kingdom· MHRA
12 products
Uses
Isoniazid is indicated in the treatment of all forms of pulmonary and extra- pulmonary tuberculosis.
How to take
USUnited States· FDA
1 product
Uses
INDICATIONS AND USAGE
Isoniazid tablets, USP are recommended for all forms of tuberculosis in which organisms are susceptible. However, active tuberculosis must be treated with multiple concomitant anti-tuberculosis medications to prevent the emergence of drug resistance.
Single-drug treatment of active tuberculosis with isoniazid or any other medication, is inadequate therapy. Isoniazid tablets, USP are recommended as preventive therapy for the following groups, regardless of age. (Note: the criterion for a positive reaction to a skin test (in millimeters of induration) for each group is given in parenthesis): Persons with human immunodeficiency virus (HIV) infection (greater than or equal to 5 mm) and persons with risk factors for HIV infection whose HIV infection status is unknown but who are suspected of having HIV infection.
Preventive therapy may be considered for HIV infected persons who are tuberculin-negative but belong to groups in which the prevalence of tuberculosis infection is high. Candidates for preventive therapy who have HIV infection should have a minimum of 12 months of therapy.
CACanada· Health Canada
7 products
7 products on record with this regulator. Detailed label text (uses, dosage, side effects) is being ingested — the original document is linked under Sources [3].
Brands in Canada (2)
Drug interactions
Known interactions involving Isoniazid. Select one for details. This list is informational and not a complete interaction checker.
Showing 240 of 450. Type above to find a specific drug.
Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.
Sources & citations
- [1]MHRA (UK) · PL363010018 · revised August 22, 2025
- [2]FDA DailyMed · 03bf3bd5-64f9-44… · revised February 16, 2026 [PDF]
- [3]Health Canada (DPD) · 00577790 · revised March 22, 2025
- [4]OpenFDA adverse-event reports (US), 12 months ending June 4, 2026.
Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.