ℹ️ Compiled from public regulatory records · Last regulator revision: May 1, 2026

Imipramine

Non-Selective Monoamine Reuptake Inhibitors

GB MHRAUS FDA

Drug class: Non-Selective Monoamine Reuptake Inhibitors
Availability: Prescription only
Routes: Oral
Markets covered: 2
Products on record: 18

N06AANon-Selective Monoamine Reuptake Inhibitors

Overview

Plain-language summary, compiled from the cited regulatory records

Imipramine is a medication classified as a non-selective monoamine reuptake inhibitor [1]. It is approved for the relief of symptoms associated with depression [1]. Endogenous depression is more likely to show improvement with this medication compared to other depressive states [1]. It may take one to three weeks of treatment before the full therapeutic benefits are observed [1].

Additionally, imipramine may be used as a temporary adjunctive therapy for reducing enuresis (bedwetting) in children aged 6 years and older [1]. This use is considered after any potential organic causes have been ruled out through appropriate medical tests [1].

Imipramine is available under several brand names [1].

This is not medical advice. Consult a qualified healthcare professional.

Regulatory status by market

Market	Regulator	Products	Last revision
GB United Kingdom	MHRA	17	May 1, 2026
US United States	FDA	1	April 13, 2026

GBUnited Kingdom· MHRA

17 products

Uses

GBOfficial regulatory label· revised September 20, 2024[1]

For the treatment of the symptoms of depressive illness and for the relief in children of nocturnal enuresis.

How to take

USUnited States· FDA

1 product

Uses

USOfficial regulatory label· revised April 13, 2026[2]

INDICATIONS AND USAGE
Depression -For the relief of symptoms of depression. Endogenous depression is more likely to be alleviated than other depressive states. One to three weeks of treatment may be needed before optimal therapeutic effects are evident. Childhood Enuresis -May be useful as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older, after possible organic causes have been excluded by appropriate tests.
In patients having daytime symptoms of frequency and urgency, examination should include voiding cystourethrography and cystoscopy, as necessary. The effectiveness of treatment may decrease with continued drug administration.

How to take

Drug interactions

Known interactions involving Imipramine. Select one for details. This list is informational and not a complete interaction checker.

Amiodarone Amisulpride Anagrelide Arbutamine Arsenic Trioxide Bedaquiline Bepridil Bupropion Buspirone Cabozantinib Ceritinib Chloroquine Cisapride Citalopram Clonidine Clozapine Crizotinib Cyclobenzaprine Dalfopristin Desvenlafaxine Dexfenfluramine Dihydroergotamine Disopyramide Dobutamine Dofetilide Dolasetron Dopamine Dronedarone Droperidol Duloxetine Efavirenz Ephedrine Epinephrine Escitalopram Fentanyl Fingolimod Flumazenil Fluoxetine Fluvoxamine Gatifloxacin Granisetron Grepafloxacin Haloperidol Hydroxychloroquine Ibutilide Iloperidone Iohexol Iopamidol Isocarboxazid Ivabradine Ivosidenib Lasmiditan Lefamulin Levomilnacipran Levonordefrin Linezolid Lorcaserin Lumefantrine Macimorelin Meperidine Metaraminol Methadone Methoxamine Methylene Blue Mifepristone Milnacipran Mirtazapine Moxifloxacin Nefazodone Nilotinib Norepinephrine Ondansetron Osimertinib Palonosetron Panobinostat Papaverine Paroxetine Pasireotide Phenelzine Phenylephrine Pimozide Potassium Chloride Potassium Citrate Procainamide Procarbazine Rasagiline Ribociclib Safinamide Saquinavir Selegiline Selpercatinib Sertraline Sibutramine Siponimod Sotalol Sparfloxacin Tapentadol Topiramate Toremifene Tramadol Tranylcypromine Trazodone Vandetanib Vemurafenib Venlafaxine Vilazodone Vortioxetine Ziprasidone Zonisamide Abarelix Abiraterone Acebutolol Acetohexamide Acetylcholine Aclidinium Acrivastine Activated Charcoal Adenosine Aldesleukin Alfentanil Alfuzosin Alprazolam Altretamine Amantadine Amifampridine Amiloride Amitriptyline Amobarbital Amoxapine Amphetamine Amprenavir Amyl Nitrite Anisindione Apalutamide Apomorphine Apraclonidine Arformoterol Aripiprazole Armodafinil Asenapine Astemizole Atazanavir Atenolol Atropine Azatadine Azithromycin Baclofen Benazepril Bendroflumethiazide Benzhydrocodone Benzphetamine Benzthiazide Berotralstat Betaxolol Bicalutamide Biperiden Bismuth Subsalicylate Bisoprolol Botulinum Toxin Type A Botulinum Toxin Type B Brexanolone Brexpiprazole Brigatinib Brivaracetam Bromocriptine Brompheniramine Bumetanide Buprenorphine Butabarbital Butalbital Butorphanol Cannabidiol Capmatinib Captopril Carbamazepine Carbinoxamine Cariprazine Carisoprodol Carteolol Carvedilol Celecoxib Cenobamate Cetirizine Chlorcyclizine Chlordiazepoxide Chlormezanone Chlorothiazide Chlorphenesin Chlorpheniramine Chlorpromazine Chlorpropamide Chlorthalidone Chlorzoxazone Cilostazol Cimetidine Cinacalcet Ciprofloxacin Clarithromycin Clemastine Clevidipine Clidinium Clobazam Clofazimine Clomipramine Clonazepam Cobicistat Codeine Cyclizine Dabrafenib Dacomitinib Dantrolene Darifenacin Dasatinib Daunorubicin Deferasirox Degarelix Deserpidine Desipramine Desmopressin Deutetrabenazine Dexmedetomidine Dexmethylphenidate Dextroamphetamine Dextrothyroxine Diazepam Diazoxide Dichloralphenazone Dicyclomine Diethylpropion Dihydrocodeine Diltiazem Diphenhydramine Donepezil Doxazosin Doxepin Doxorubicin Doxylamine Dronabinol Duvelisib Eliglustat

Showing 240 of 600. Type above to find a specific drug.

Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.

Sources & citations

[1]MHRA (UK) · PL334140052 · revised September 20, 2024
[2]FDA DailyMed · 02c19a0a-3d9d-48… · revised April 13, 2026 [PDF]

Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.