Icodextrin

48 g/L sodium lactate 257 mg/L calcium chloride 51 mg/L magnesium chloride Hydrochloric acid (For pH adjustment) Sodium Hydroxide (For pH adjustment) Water for Injection INDICATIONS AND CLINICAL USE EXTRANEAL (icodextrin, sodium chloride, sodium lactate, calcium chloride, magnesium chloride) is indicated for use as an osmotic agent for long dwell, up to 12 hours, in continuous ambulatory peritoneal dialysis (CAPD) or automated peritoneal dialysis (APD), where it can be used for 14 and up to 16 hours.

, corn starch) and/or icodextrin ▪ maltose or isomaltose intolerance. ▪ glycogen storage disease ▪ pre-existing severe lactic acidosis ▪ uncorrectable mechanical defects that prevent effective PD or increase the risk of infection ▪ documented loss of peritoneal function or extensive adhesions that compromise peritoneal function ▪ The product is also contra-indicated in patients with a history of abdominal surgery in the month preceding commencement of therapy, patients with abdominal fistulae, EXTRANEAL (icodextrin, sodium chloride, sodium lactate, calcium chloride, magnesium chloride) Page 4 of 28 tumors, open wounds, herniae or other conditions which compromise the integrity of the abdominal wall, abdominal surface or intra-abdominal cavity - in common with other peritoneal dialysis fluids until healing is complete.