Hydroxyzine
Diphenylmethane Derivatives
- Drug class
- Diphenylmethane Derivatives
- Availability
- Prescription only
- Routes
- Oral, Intramuscular
- Markets covered
- 3
- Products on record
- 35
Overview
Hydroxyzine is an active pharmaceutical ingredient in the Diphenylmethane Derivatives group (N05BB). The information below is compiled per regulator from the product labels on record, with direct links to the original documents.
Regulatory status by market
| Market | Regulator | Products | Last revision |
|---|---|---|---|
| US United States | FDA | 17 | March 30, 2026 |
| GB United Kingdom | MHRA | 14 | April 24, 2026 |
| CA Canada | Health Canada | 4 | March 22, 2025 |
USUnited States· FDA
17 products
Uses
INDICATIONS
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses, and in histamine-mediated pruritus.
As a sedative when used as premedication and following general anesthesia, hydroxyzine may potentiate meperidine (Demerol ® ) and barbiturates, so their use in pre-anesthetic adjunctive therapy should be modified on an individual basis.
Atropine and other belladonna alkaloids are not affected by the drug. Hydroxyzine is not known to interfere with the action of digitalis in any way and it may be used concurrently with this agent. The effectiveness of hydroxyzine as an antianxiety agent for long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies.
GBUnited Kingdom· MHRA
14 products
Uses
Symptomatic treatment of anxiety in adults. Symptomatic treatment of pruritus in adults and children ≥ 6 years of age.
How to take
CACanada· Health Canada
4 products
Uses
HYDROXYZINE (hydroxyzine hydrochloride) is indicated in adults for: • Management of anxiety. • Pre-medication, such as preparation for dental procedures. • Management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses.
• Control of nausea and vomiting, excluding nausea and vomiting of pregnancy (see
How to take
Drug interactions
Known interactions involving Hydroxyzine. Select one for details. This list is informational and not a complete interaction checker.
Showing 240 of 600. Type above to find a specific drug.
Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.
Sources & citations
- [1]FDA DailyMed · 02616eee-a1a4-4a… · revised December 16, 2024 [PDF]
- [2]MHRA (UK) · PL317740049 · revised July 18, 2025
- [3]Health Canada (DPD) · 00646016 · revised March 22, 2025
Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.