Histamine
Active ingredient
Sold as SOLUPRICK POSITIVE AND…
- Drug class
- -
- Availability
- Prescription only
- Routes
- Percutaneous, Intradermal
- Markets covered
- 3
- Products on record
- 4
Overview
Plain-language summary, compiled from the cited regulatory records
Histamine is a biogenic amine that plays a role in local immune responses and regulates physiological functions in the brain and gut [1]. It is a chemical mediator involved in immediate hypersensitivity reactions, commonly known as Type I allergies [1].
Histamine is approved for use as a positive control in the evaluation of allergenic skin testing [1]. This means it is used to confirm that a patient's skin is capable of reacting to stimuli, ensuring the accuracy of allergy tests [1].
This active ingredient is available under various brand names. In the past 12 months, there have been no adverse event reports submitted for this substance [2].
This is not medical advice. Consult a qualified healthcare professional.
Regulatory status by market
| Market | Regulator | Products | Last revision |
|---|---|---|---|
| GB United Kingdom | MHRA | 2 | April 10, 2026 |
| US United States | FDA | 1 | August 28, 2020 |
| CA Canada | Health Canada | 1 | July 11, 2025 |
GBUnited Kingdom· MHRA
2 products
Uses
This medicinal product is for diagnostic use only. Positive and negative control of skin-prick tests for diagnosis of specific IgE- mediated allergy.
How to take
USUnited States· FDA
1 product
Uses
INDICATIONS AND USAGE
For use as a positive control in evaluation of allergenic (immediate hypersensitivity or "Type I") skin testing.
How to take
CACanada· Health Canada
1 product
Uses
AND CLINICAL USE
Positive Skin Test Control – Histamine is indicated as an adjunct in allergy skin test for diagnosis, as a positive control to test wheal-flare response of skin for evaluation of skin test response to allergenic extracts. CONTRAINDICATIONS Positive Skin Test Control – Histamine is contraindicated in patients with a history of hypersensitivity to histamine products, and in patients with hypotension, severe hypertension, vasomotor instability, severe cardiac, pulmonary or renal disease.
WARNINGS:
Attacks of severe asthma or other serious allergic conditions may be precipitated by the administration of Histamine Dihydrochloride in patients with bronchial disease. Caution is advised in using histamine in such patients and in those with a history of bronchial asthma.
Histamine Dihydrochloride has not been approved for unlabeled use as gastric acid stimulus or for detecting bronchial hyperactivity.
Drug interactions
Known interactions involving Histamine. Select one for details. This list is informational and not a complete interaction checker.
Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.
Sources & citations
- [1]MHRA (UK) · PL100850019 · revised October 3, 2025
- [2]FDA DailyMed · 1159c24c-d9ce-49… · revised August 28, 2020 [PDF]
- [3]Health Canada (DPD) · 02439514 · revised July 11, 2025
Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.