Finerenone

).

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C=Case Study; CT=Clinical Trial; T=Theoretical Note: The effects of itraconazole, clarithromycin, fluvoxamine, rifampicin and efavirenz on finerenone exposure are predictions based on PBPK simulations. No clinical data was available to evaluate effects of strong and weak CYP3A4 inhibitors or strong and moderate CYP3A4 inducers on finerenone exposure.

75 h), compared to administration under fasted conditions. This was paralleled by an increase in extent of absorption (AUC). 75 h), and increase in AUC. 3 Pharmacokinetics, Effect of food). 25 hours and Cmax decreased by approximately 23%.

4 Administration). Concomitant intake of grapefruit or grapefruit juice is expected to increase the plasma concentration of finerenone and should be avoided (see 4 Dosage and Administration and 7 Warnings and Precautions, General). 6 Drug-Herb Interactions Avoid concomitant use of KERENDIA with St John’s Wort (a strong CYP3A4 inducer) which may markedly decrease finerenone exposure and result in reduced therapeutic effect.