Famotidine
H2-Receptor Antagonists
Sold as Pepcid AC · acid controller · heartburn relief · Curist Acid Relief · ACID CONTROL
- Drug class
- H2-Receptor Antagonists
- Availability
- Prescription and OTC
- Routes
- Oral, Intravenous
- Markets covered
- 3
- Products on record
- 89
- FDA reports (12 mo)
- 9,598
Overview
Plain-language summary, compiled from the cited regulatory records
Famotidine is a medication classified as an H2-receptor antagonist [1]. It is approved for use in adult and pediatric patients weighing 40 kg and greater for the treatment of active duodenal ulcers and active gastric ulcers [1]. Famotidine is also indicated for symptomatic nonerosive gastroesophageal reflux disease (GERD) and for erosive esophagitis due to GERD, which has been diagnosed by biopsy [1]. In adults, it is approved for treating pathological hypersecretory conditions, such as Zollinger-Ellison syndrome and multiple endocrine neoplasias [1].
This medication is available under various brand names, including some marketed for heartburn relief and as an acid reducer [1]. In the past 12 months, there have been 9,598 adverse event reports associated with famotidine [2]. The most frequently reported adverse reactions include nausea, diarrhea, fatigue, off-label use, and headache [2].
This is not medical advice. Consult a qualified healthcare professional.
Regulatory status by market
| Market | Regulator | Products | Last revision |
|---|---|---|---|
| US United States | FDA | 33 | May 29, 2026 |
| CA Canada | Health Canada | 28 | June 1, 2026 |
| GB United Kingdom | MHRA | 28 | May 22, 2026 |
USUnited States· FDA
33 products
Uses
1 INDICATIONS AND USAGE Famotidine tablets are indicated in adult and pediatric patients 40 kg and greater for the treatment of: • active duodenal ulcer (DU). • active gastric ulcer (GU). • symptomatic nonerosive gastroesophageal reflux disease (GERD).
• erosive esophagitis due to GERD, diagnosed by biopsy. , Zollinger-Ellison syndrome, multiple endocrine neoplasias). • reduction of the risk of duodenal ulcer recurrence.
Famotidine tablets are a histamine-2 (H 2 ) receptor antagonist indicated ( 1 ):
In adult and pediatric patients 40 kg and greater for the treatment of: • active duodenal ulcer (DU). • active gastric ulcer. • symptomatic nonerosive gastroesophageal reflux disease (GERD). • erosive esophagitis due to GERD, diagnosed by biopsy.
, Zollinger-Ellison syndrome, multiple endocrine neoplasias). • reduction of the risk of DU recurrence.
CACanada· Health Canada
28 products
Uses
PEPCID AC®/ MAXIMUM STRENGTH PEPCID® AC (famotidine) is indicated for: • the treatment of conditions where a controlled reduction of gastric secretion is required, such as acid indigestion, heartburn, sour or upset stomach; • the prevention of acid indigestion, heartburn, sour or upset stomach when associated with the consumption of food and/or beverage including nocturnal symptoms associated with the evening meal and expected to cause sleep disturbance.
1 Pediatrics Pediatrics (<12 years of age): Safety and effectiveness in children have not been established. PEPCID AC®/ MAXIMUM STRENGTH PEPCID® AC should not be administered to children under 12 years of age. 3 Pharmacokinetics).
How to take
GBUnited Kingdom· MHRA
28 products
Uses
Duodenal ulcer - Benign gastric ulcer - Zollinger-Ellison syndrome - Treatment of mild to moderate reflux oesophagitis
How to take
Drug interactions
Known interactions involving Famotidine. Select one for details. This list is informational and not a complete interaction checker.
Showing 240 of 600. Type above to find a specific drug.
Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.
Sources & citations
- [1]FDA DailyMed · 002875d2-8c30-2d… · revised October 22, 2025 [PDF]
- [2]Health Canada (DPD) · 02185938 · revised December 29, 2025
- [3]MHRA (UK) · PL538350054 · revised January 30, 2026
- [4]OpenFDA adverse-event reports (US), 12 months ending June 4, 2026.
Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.