Etoposide

Testicular cancer Etoposide is indicated in combination with other approved chemotherapeutic agents for the treatment of first line, recurrent or refractory testicular cancer in adults. Small cell lung cancer Etoposide is indicated in combination with other approved chemotherapeutic agents for the treatment of small-cell lung cancer in adults.

Hodgkin’s lymphoma Etoposide is indicated in combination with other approved chemotherapeutic agents for the treatment of Hodgkin’s lymphoma in adult and paediatric patients. Non-Hodgkin’s lymphoma Etoposide is indicated in combination with other approved chemotherapeutic agents for the treatment of non-Hodgkin’s lymphoma in adult and paediatric patients.

Acute myeloid leukaemia Etoposide is indicated in combination with other approved chemotherapeutic agents for the treatment of acute myeloid leukaemia in adult and paediatric patients. Gestational trophoblastic neoplasia Etoposide is indicated for first line and second line therapy in combination with other approved chemotherapeutic agents for the treatment of high risk gestational trophoblastic neoplasia in adults.

VEPESID (etoposide) is indicated for:

Small Cell Carcinoma of the Lung • first-line therapy in combination with other established antineoplastic agents. • second-line combination or single agent therapy in patients who have not responded or relapsed on other chemotherapeutic regimens.

Malignant Lymphoma (histiocytic type) • first-line therapy in combination with other established antineoplastic agents. Non-small Cell Carcinoma of the Lung • for patients considered ineligible for surgery, etoposide has been shown effective alone or in combination with PLATINOL (cisplatin).

• for patients who require chemotherapy following surgery. Testicular Malignancies (germ cell tumours including seminomas) • in combination with other effective chemotherapeutic agents in patients who have already received appropriate therapy.

1 Pediatrics Pediatrics(<18 years of age): No data are available to Health Canada; therefore, Health Canada has not authorized an indication for pediatric use. 2 Geriatrics Geriatrics: No data are available to Health Canada; therefore, Health Canada has not authorized an indication for geriatric use.

INDICATIONS AND USAGE

Etoposide Injection is indicated in the management of the following neoplasms:

Refractory Testicular Tumors Etoposide Injection in combination therapy with other approved chemotherapeutic agents in patients with refractory testicular tumors who have already received appropriate surgical, chemotherapeutic, and radiotherapeutic therapy.

Small Cell Lung Cancer Etoposide Injection and/or capsules in combination with other approved chemotherapeutic agents as first line treatment in patients with small cell lung cancer.