Dexrazoxane
Detoxifying Agents For Antineoplastic Treatment
Sold as Savene · ZINECARD
- Drug class
- Detoxifying Agents For Antineoplastic Treatment
- Availability
- See label
- Routes
- Intravenous
- Markets covered
- 3
- Products on record
- 7
Overview
Dexrazoxane is an active pharmaceutical ingredient in the Detoxifying Agents For Antineoplastic Treatment group (V03AF). The information below is compiled per regulator from the product labels on record, with direct links to the original documents.
Regulatory status by market
| Market | Regulator | Products | Last revision |
|---|---|---|---|
| CA Canada | Health Canada | 4 | July 23, 2025 |
| GB United Kingdom | MHRA | 2 | December 6, 2024 |
| EU European Union | EMA | 1 | September 6, 2024 |
CACanada· Health Canada
4 products
Uses
Dexrazoxane for injection (dextrazoxane for injection) is indicated for: • Reducing (preventing) the incidence and severity of cardiotoxicity associated with doxorubicin administration for the treatment of metastatic breast cancer in patients who have already experienced a partial response or at least maintained stable disease.
Dexrazoxane for Injection should be used only with chemotherapy regimens containing doxorubicin. There is some evidence that the use of dexrazoxane concurrently with the initiation of fluorouracil, doxorubicin and cyclophosphamide (FAC) therapy interferes with the antitumour efficacy of the regimen, and this use is not recommended.
Dexrazoxane for Injection should be used only after tolerance to a full dose doxorubicin has been established (see 7 WARNINGS AND PRECAUTIONS). 3 Pediatrics). 4 Geriatrics).
GBUnited Kingdom· MHRA
2 products
Uses
Cardioxane is indicated in adults for the prevention of chronic cumulative cardiotoxicity caused by anthracycline use in advanced and/or metastatic breast cancer patients who have received a prior cumulative dose of 300 mg/m2 of doxorubicin or a prior cumulative dose of 540 mg/m2 of epirubicin when further anthracycline treatment is required.
How to take
EUEuropean Union· EMA
1 product
Uses
Savene is indicated in adults for the treatment of anthracycline extravasation.
How to take
Drug interactions
Known interactions involving Dexrazoxane. Select one for details. This list is informational and not a complete interaction checker.
Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.
Sources & citations
- [1]Health Canada (DPD) · 02557649 · revised July 23, 2025
- [2]MHRA (UK) · PL196350007 · revised December 6, 2024
- [3]European Medicines Agency · EMEA/H/C/000682 · revised September 6, 2024
Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.