Dexmedetomidine

For sedation of adult ICU (Intensive Care Unit) patients requiring a sedation level not deeper than arousal in response to verbal stimulation (corresponding to Richmond Agitation-Sedation Scale (RASS) 0 to -3). , procedural/awake sedation.

Precedex® (Dexmedetomidine Hydrochloride for Injection, Dexmedetomidine Hydrochloride Injection) is indicated for: • Intensive Care Unit Sedation Precedex® is indicated for sedation of initially intubated and mechanically ventilated adult patients during treatment in an intensive care setting by continuous intravenous infusion.

The Precedex® infusion should not generally exceed 24 hours. Precedex® has been continuously infused in mechanically ventilated patients prior to extubation, during extubation, and post-extubation. It is not necessary to discontinue Precedex® prior to extubation.

• Conscious Sedation Precedex® is indicated for sedation of non-intubated adult patients prior to and/or during surgical and other procedures by continuous intravenous infusion for the following procedures: - Monitored Anesthesia Care (MAC) with an adequate nerve block and/or local infiltration; and - Awake Fiberoptic Intubation (AFI) with adequate topical preparation of the upper airway with local lidocaine formulations.

1 INDICATIONS AND USAGE Dexmedetomidine Injection and Dexmedetomidine in 5% Dextrose Injection is a alpha 2 adrenergic receptor agonist indicated for: • Sedation of initially intubated and mechanically ventilated adult patients during treatment in an intensive care setting.

Administer Dexmedetomidine Injection and Dexmedetomidine in 5% Dextrose Injection by continuous infusion not to exceed 24 hours. 1) • Sedation of non-intubated adult patients prior to and/or during surgical and other procedures. 1 Intensive Care Unit Sedation Dexmedetomidine Injection and Dexmedetomidine in 5% Dextrose Injection is indicated for sedation of initially intubated and mechanically ventilated adult patients during treatment in an intensive care setting.

Dexmedetomidine Injection and Dexmedetomidine in 5% Dextrose Injection should be administered by continuous infusion not to exceed 24 hours. 2 Procedural Sedation Dexmedetomidine Injection and Dexmedetomidine in 5% Dextrose Injection is indicated for sedation of non-intubated adult patients prior to and/or during surgical and other procedures.

For sedation of adult ICU (Intensive Care Unit) patients requiring a sedation level not deeper than arousal in response to verbal stimulation (corresponding to Richmond Agitation-Sedation Scale (RASS) 0 to -3). e. procedural/awake sedation.