Cinacalcet
Other Anti-Parathyroid Agents
Sold as Mimpara · Parareg
- Drug class
- Other Anti-Parathyroid Agents
- Availability
- Prescription only
- Routes
- Oral
- Markets covered
- 4
- Products on record
- 106
- FDA reports (12 mo)
- 393
Overview
Plain-language summary, compiled from the cited regulatory records
Cinacalcet is a medication classified as an Other Anti-Parathyroid Agent [1]. It is approved for treating secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) who are on dialysis [1]. Cinacalcet is also indicated for managing hypercalcemia in adult patients diagnosed with parathyroid carcinoma (PC) [1]. Additionally, it is used for hypercalcemia in adult patients with primary HPT when parathyroidectomy would typically be considered [1].
It is important to note that cinacalcet tablets are not intended for use in patients with CKD who are not undergoing dialysis [1].
In the past 12 months, there have been 393 adverse event reports associated with cinacalcet [2]. The most frequently reported adverse events include off-label use, diarrhea, drug ineffectiveness, death, and nausea [2].
This is not medical advice. Consult a qualified healthcare professional.
Regulatory status by market
| Market | Regulator | Products | Last revision |
|---|---|---|---|
| GB United Kingdom | MHRA | 59 | May 29, 2026 |
| CA Canada | Health Canada | 39 | May 22, 2026 |
| US United States | FDA | 6 | February 18, 2026 |
| EU European Union | EMA | 2 | May 7, 2026 |
GBUnited Kingdom· MHRA
59 products
Uses
Secondary hyperparathyroidism Adults Treatment of secondary hyperparathyroidism (HPT) in adult patients with end-stage renal disease (ESRD) on maintenance dialysis therapy. 4). 1). Parathyroid carcinoma and primary hyperparathyroidism in adults Reduction of hypercalcaemia in adult patients with: • parathyroid carcinoma.
• primary HPT for whom parathyroidectomy would be indicated based on serum calcium levels (as defined by relevant treatment guidelines), but in whom parathyroidectomy is not clinically appropriate or is contraindicated.
How to take
CACanada· Health Canada
39 products
Uses
AND CLINICAL USE......................................................................................... 3 CONTRAINDICATIONS ..............................................................................................................
4 WARNINGS AND PRECAUTIONS ............................................................................................. 4 ADVERSE REACTIONS ...............................................................................................................
8 DRUG INTERACTIONS ............................................................................................................. 11 DOSAGE AND ADMINISTRATION .........................................................................................
12 OVERDOSAGE ............................................................................................................................ 13 ACTION AND CLINICAL PHARMACOLOGY ......................................................................
USUnited States· FDA
6 products
Uses
1 INDICATIONS AND USAGE Cinacalcet is a positive modulator of the calcium sensing receptor indicated for: Secondary Hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on dialysis. 1 ) Limitations of Use : Cinacalcet tablets are not indicated for use in patients with CKD who are not on dialysis Hypercalcemia in adult patients with Parathyroid Carcinoma (PC).
2 ) Hypercalcemia in adult patients with primary HPT for whom parathyroidectomy would be indicated on the basis of serum calcium levels, but who are unable to undergo parathyroidectomy. 1 )]. 1 )]. 2 )] . 3 Primary Hyperparathyroidism Cinacalcet tablets are indicated for the treatment of hypercalcemia in adult patients with primary HPT for whom parathyroidectomy would be indicated on the basis of serum calcium levels, but who are unable to undergo parathyroidectomy.
3 )] .
EUEuropean Union· EMA
2 products
Uses
Secondary hyperparathyroidism Adults Treatment of secondary hyperparathyroidism (HPT) in adult patients with end-stage renal disease (ESRD) on maintenance dialysis therapy. 4). 1). Parathyroid carcinoma and primary hyperparathyroidism in adults Reduction of hypercalcaemia in adult patients with: • parathyroid carcinoma.
• primary HPT for whom parathyroidectomy would be indicated on the basis of serum calcium levels (as defined by relevant treatment guidelines), but in whom parathyroidectomy is not clinically appropriate or is contraindicated.
How to take
Drug interactions
Known interactions involving Cinacalcet. Select one for details. This list is informational and not a complete interaction checker.
Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.
Sources & citations
- [1]MHRA (UK) · PLGB482590075 · revised November 7, 2025
- [2]Health Canada (DPD) · 02441624 · revised May 22, 2026
- [3]FDA DailyMed · 02b8c11b-99e8-40… · revised December 12, 2025 [PDF]
- [4]European Medicines Agency · EMEA/H/C/004014 · revised May 7, 2026
- [5]OpenFDA adverse-event reports (US), 12 months ending June 4, 2026.
Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.