ZACIN

Adults and the elderly For topical administration to unbroken skin. Apply only a small amount of cream (pea size) to affected area 4 times daily. These applications should be evenly spaced throughout the waking hours and not more often than every 4 hours.

The cream should be gently rubbed in, there should be no residue left on the surface. Zacin may cause transient burning on application. The burning is observed more frequently when application schedules of more than 4 times daily are used.

Hands should be washed immediately after application of Zacin unless hands and fingers are being treated. Zacin should not be applied near the eyes. Pain relief usually begins within the first week of treatment and increases with continuing regular application for the next two to eight weeks.

Not suitable for use in children.

Zacin may cause skin irritation or transient burning on application. This burning is observed more frequently when application schedules of more than 4 times daily are utilised. The burning can be enhanced if too much cream is used and if it is applied just before or after a bath or shower.

Irritation of the mucous membranes of the eyes and respiratory tract (such as nasal and throat irritation) on application of Zacin cream has been reported rarely, resulting in symptoms such as coughing, sneezing and runny eyes. These events are usually mild and self-limiting.

There have been a few reports of dyspnoea, wheezing and exacerbation of asthma. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product.

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Skin irritation has been reported following application of Zacin. The hands should be washed immediately after application of the cream, unless the hands are the treated areas, in which case, they should be washed 30 minutes after application Contact with eyes and mucous membranes should be avoided.

Patients should avoid taking a hot bath or shower just before or after applying Zacin, as it can enhance the burning sensation. Patients and carers should avoid inhalation of vapours from the cream, as transient irritation of the mucous membranes of the eyes and respiratory tract (including exacerbation of asthma) has been reported.

Keep Zacin away from the eyes. Medical advice should be sought if the condition worsens, or clears up then recurs. Tight bandages should not be applied on top of Zacin cream. Excipients Benzyl alcohol may cause mild local irritation. g.

contact dermatitis).

Zacin cream is contra-indicated on broken or irritated skin. 1.