VAMIN

Posology Adults Depending upon patient requirements up to one litre intravenously per 24 hours. Vamin 14 is administered by slow intravenous infusion at approximately 40 drops per minute or slower corresponding to an infusion time of at least eight hours per litre.

Elderly Age per se requires no adjustment of the adult dosage. However, caution should be exercised in the “frail” elderly, and indeed in all patients with poor renal, cardiac or liver function, where smaller volumes should be used depending on the individual patients’ requirements and condition.

Paediatric Population Infants Can be administered at the physician’s discretion. An amino acid solution containing larger amounts of cysteine/cystine and tyrosine may be considered more appropriate in infants. Method of administration For intravenous use only.

6).

Vomiting, flushing and sweating may occur, rarely, particularly if the recommended rate of infusion is exceeded. Abnormal liver function tests have been observed during intravenous infusion, but these return to normal when artificial feeding is stopped.

Cholestasis has been reported in some patients receiving intravenous nutrition. Thrombophlebitis may occur when peripheral veins are used but the incidence is reduced by the simultaneous infusion of fat emulsion. Reporting of suspected adverse reactions Reporting of suspected adverse reactions after authorisation of the medicinal product is important.

It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard.

• Care must be exercised in the administration of large volume infusion fluids to patients with cardiac insufficiency. • Amino acid infusions must also be administered with caution to patients with disturbances in protein metabolism.

• Hyperkalaemia, hypernatraemia and acidosis should be corrected prior to commencement of intravenous nutrition; serum electrolytes, blood glucose levels, acid-base balance, and fluid levels should be regularly monitored. g. g. digitalis.

• Potassium replacement should be carefully controlled, as plasma potassium levels may not be directly related to tissue levels. • Light exposure of solutions for intravenous parenteral nutrition, especially after admixture with trace elements and/or vitamins, may have adverse effects on clinical outcome in neonates, due to generation of peroxides and other degradation products.

6).

1 Vamin 14 is contraindicated in patients with irreversible liver damage and in severe uraemia when dialysis facilities are not available.