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TIMODINE is a brand name for Nystatin. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: For the treatment of dermatoses, including intertrigo, eczema, seborrhoeic dermatitis, hand dermatitis, and pruritis ani et vulvae, in which infection with Candida albicans is a factor. For the treatment of severe nappy rash in which infection with C. albicans is a factor.
Verbatim from this product's MHRA label. Tap a section to expand.
For topical application to the skin.
Adults (including the elderly) and children Dermatoses:
Sufficient Timodine Cream should be applied to cover the lesion in a thin layer. It should then be massaged into the skin until the cream disappears. The treatment should be repeated three times a day until the lesion has healed. There is no indication that dosage need be modified for the elderly.
Nappy rash:
After removal of the soiled nappy, the affected area should be cleaned and dried, and a thin layer of Timodine Cream applied. The treatment should be repeated after every nappy change. In infants long-term continuous topical steroid therapy should be avoided since this can lead to adrenal suppression even without occlusion.
A course of treatment should not normally exceed seven days.
Tabulated list of adverse reactions Undesirable effects are listed by MedDRA System Organ Classes. 4). *see section ‘Description of selected adverse reactions’. Description of selected adverse reactions If signs of hypersensitivity appear, application should stop immediately.
Thinning of the skin may be restored over a period after stopping treatment but the original structure may never return. Mild depigmentation may be reversible. Exacerbation of symptoms may occur. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important.
It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.
In order to minimise the side effects of a topical corticosteroid, it is important to apply it thinly to the affected areas only. Topical corticosteroids should not be applied with an occlusive dressing to large areas of the body. Absorption is greatest on thin/raw skin, intertriginous areas, and under occlusion.
Skin thinning is more likely if corticosteroids are applied under occlusion. The label will state mild steroid. 9 ‘Overdose’), depending on the area of the body being treated and the duration of treatment. Avoid prolonged exposure on the face and keep away from the eyes.
Use with caution on broken skin. Prolonged use of compound preparations such as Timodine Cream can increase the likelihood of resistance and of sensitization. Mixing topical preparations on the skin should be avoided where possible; several minutes should elapse between application of different preparations.
Topical corticosteroids are not recommended for acne vulgaris, may worsen secondary infected lesions, and should not be used indiscriminately in pruritis. Long term use of topical steroids can result in the development of rebound flares after stopping treatment (topical steroid withdrawal syndrome).
A severe form of rebound flare can develop which takes the form of a dermatitis with intense redness, stinging and burning that can spread beyond the initial treatment area. It is more likely to occur when delicate skin sites such as the face and flexures are treated.
Should there be a reoccurrence of the condition within days to weeks after successful treatment a withdrawal reaction should be suspected. Reapplication should be with caution and specialist advice is recommended in these cases or other treatment options should be considered.
g. contact dermatitis) and propylene glycol (E1520), which may cause skin irritation. Butylated hydroxyanisole (E320) may cause irritation to the eyes and mucous membranes. Timodine Cream also contains propyl hydroxybenzoate (E216) and methyl hydroxybenzoate (E218), both of which may cause allergic reactions, which may be delayed.
1 ‘List of excipients’).
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Nystatin in United Kingdom.
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Brand names are compiled from public regulatory records for active-ingredient mapping only. Drugvu is not affiliated with any manufacturer. This is not medical advice.
Nystatin can rarely cause contact dermatitis, and allergic reactions can occur after use of benzalkonium chloride. Instruct patients not to smoke or go near naked flames – risk of severe burns. Fabric (clothing, bedding, dressings etc) that has been in contact with this product burns more easily and is a serious fire hazard.
Washing clothing and bedding may reduce build-up but not totally remove it. The elderly The skin of the elderly is often relatively atrophic so that local and systemic side effects of hydrocortisone are more likely. Patients with hepatic failure The reduced metabolism of hydrocortisone in patients with hepatic failure increases the theoretical risk of adrenal suppression.
Paediatric population Avoid prolonged use in children. Caution is required in dermatoses of infancy including nappy rash. Care should be taken as the nappy can act as an occlusive dressing and thus allow an increase in absorption of the steroid component of the cream.
In infants, long-term continuous topical steroid therapy should be avoided since this can lead to adrenal suppression even without occlusion. A course of treatment should not normally exceed seven days. Use of hydrocortisone should be avoided in neonates.
Any proposed use of hydrocortisone in neonates should be carefully assessed, as the high body surface area:weight ratio allows a proportionate increase in percutaneous absorption. Consideration should be given to the relative fragility of neonatal skin.