RESOLVE EXTRA

Posology Route of administration: oral.

Method of administration:

Dissolve the contents of the sachet in a glass of water (150 - 200 ml) before taking.

Adults aged 18 years and over:

One sachet every 4 hours as required. Do not take more than 4 sachets in any 24 hours. The elderly may take the normal adult dose Not to be given to children under 18 years of age

Paracetamol:

Adverse effects of paracetamol are rare, but hypersensitivity including skin rashes and other allergies may occur. There have been reports of blood dyscrasias including thrombocytopenia and agranulocytosis, but these are not necessarily causally related to paracetamol.

Caffeine The most commonly reported adverse events following dosing with caffeine are GI irritation and CNS stimulation. Adverse CNS effects include insomnia, restlessness, nervousness; adverse GI effects include nausea, vomiting and gastric irritation.

4). Pyroglutamic acidosis may occur as a consequence of low glutathione levels in these patients. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important.

It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard or search for ‘MHRA Yellow Card’ in the Google Play or Apple App Store.

Care is advised in the administration of this product to patients with severe renal or severe hepatic impairment. The hazards of overdose with paracetamol are greater in those with noncirrhotic, alcoholic liver disease. Excessive intake of tea or coffee should be avoided while taking this product.

This product contains dextrose (glucose) and patients should consult their physician if they are suffering from diabetes before using this product. Oral sodium bicarbonate may increase blood pressure or cause fluid retention and pulmonary oedema in those at risk.

Sodium-containing salts should be given extremely cautiously to patients with heart failure, oedema, renal impairment, hypertension, pre-eclampsia and aldosteronism. Patients with rare hereditary glucose-galactose malabsorption should not take this medicine.

g. chronic alcoholism) who were treated with paracetamol at a therapeutic dose for a prolonged period or a combination of paracetamol and flucloxacillin. If HAGMA due to pyroglutamic acidosis is suspected, prompt discontinuation of paracetamol and close monitoring is recommended.

The measurement of urinary 5-oxoproline may be useful to identify pyroglutamic acidosis as underlying cause of HAGMA in patients with multiple risk factors. Resolve Extra® contains 454mg of sodium per sachet, equivalent to 23% of the WHO recommended daily intake of 2g sodium for an adult.

Do not exceed the stated dose. Patients should be advised not to take other paracetamol-containing products concurrently. If symptoms persist, consult your doctor. Keep out of the sight and reach of children. Consult your doctor if you are taking warfarin.

1. • Patients on sodium restricted diets. • Patients with hypochloraemia.