RESOLVE

Posology For oral administration Method of administration:

Dissolve the contents of the sachet in a glass of water (150 - 200 ml) before taking.

Adults and children aged 16 years and over:

One sachet every 4 hours as required. Do not take more than 4 sachets in any 24 hours. Not to be given to children under 16 years of age. The elderly may take the normal adult dose.

The active ingredients are usually well tolerated in normal use. Adverse effects of paracetamol are rare, but hypersensitivity including skin rashes and other allergies may occur. There have been reports of blood dyscrasias including thrombocytopenia and agranulocytosis, but these are not necessarily causally related to paracetamol.

4). Pyroglutamic acidosis may occur as a consequence of low glutathione levels in these patients. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important.

It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard or search for ‘MHRA Yellow Card’ in the Google Play or Apple App Store.

Concomitant use of other paracetamol containing medicines should be avoided. Consult your doctor if you are taking warfarin. Care is advised in the administration of this product to patients with renal or severe hepatic impairment. The hazards of overdose with paracetamol are greater in those with non-cirrhotic, alcoholic liver disease.

Resolve® includes 4 g of glucose per sachet. This should be taken into account in patients with diabetes mellitus. Patients with rare hereditary problems of fructose intolerance, glucose- galactose malabsorption of sucrase-isomaltase insufficiency should not take this medicine.

Potassium-containing salts should be given with considerable care to the elderly, patients with diabetes or any other conditions that may predispose to them to hyperkalaemia. Resolve® contains 290mg of sodium per sachet, equivalent to 12% of the WHO recommended maximum daily intake of 2g sodium for an adult.

g. chronic alcoholism) who were treated with paracetamol at a therapeutic dose for a prolonged period or a combination of paracetamol and flucloxacillin. If HAGMA due to pyroglutamic acidosis is suspected, prompt discontinuation of paracetamol and close monitoring is recommended.

The measurement of urinary 5-oxoproline may be useful to identify pyroglutamic acidosis as underlying cause of HAGMA in patients with multiple risk factors. Do not exceed the recommended dose. If symptoms persist, consult your doctor.

Keep this medicine out of the sight and reach of children.

1 Hepatic or severe renal impairment. Patients on sodium - or potassium - restricted diets. Patients with hypochloraemia and hyperkalaemia. Patients with cardiac disease.