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MACROGOL COMPOUND is a brand name for Sodium. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: For the treatment of chronic constipation.
Verbatim from this product's MHRA label. Tap a section to expand.
Posology Chronic constipation A course of treatment for chronic constipation with Macrogol compound powder for oral solution does not normally exceed 2 weeks, although this can be repeated if required. As for all laxatives, prolonged use is not usually recommended.
Extended use may be necessary in the care of patients with severe chronic or resistant constipation, secondary to multiple sclerosis or Parkinson’s Disease, or induced by regular constipating medication in particular opioids and antimuscarinics.
Adults, adolescents and the elderly: 1-3 sachets daily in divided doses, according to individual response. For extended use, the dose can be adjusted down to 1 or 2 sachets daily.
Children below 12 years old:
Not recommended.
Patients with renal insufficiency:
No dosage change is necessary. Method of administration The oral solution is for oral use. Each sachet should be dissolved in 125 ml water.
8. g. oedema, shortness of breath, increasing fatigue, dehydration, cardiac failure) Macrogol compound powder for oral solution should be stopped immediately and electrolytes measured, and any abnormality should be treated appropriately.
5). Seizure Cases of seizures associated with use of macrogol 3350 with electrolytes for bowel preparation were observed in patients either with or without prior history of seizures. 8). Use caution when prescribing macrogol 3350 with electrolytes in patients with a history of seizures, at increased risk of seizure or at risk of electrolyte disturbance.
In case of neurologic symptoms, fluid and electrolyte abnormalities should be corrected. 8) of macrogol 3350 with electrolytes for bowel preparation has been reported post-marketing, mostly in elderly patients. Advise patients to stop administration and seek immediate medical assistance if they experience incoercible vomiting and subsequent chest, neck, and abdominal pain, dysphagia, hematemesis or dyspnoea.
Ischaemic colitis Post-marketing cases of ischaemic colitis, including serious, have been reported in patients treated with macrogol for bowel preparation. Macrogol should be used with caution in patients with known risk factors for ischaemic colitis or in case of concomitant use of stimulant laxatives (such as bisacodyl or sodium picosulfate).
Patients presenting with sudden abdominal pain, rectal bleeding or other symptoms of ischaemic colitis should be evaluated promptly. e. essentially ‘potassium-free’. This medicine contains 187 mg sodium per sachet, equivalent to 9% of the WHO recommended maximum daily intake of 2 g sodium for an adult.
The maximum daily dose of this product is equivalent to 28% of the WHO recommended maximum daily intake for sodium. Macrogol compound powder for oral solution is considered high in sodium. This should be particularly taken into account for those on a low salt diet.
The fluid content of Macrogol compound powder for oral solution when re-constituted with water does not replace regular fluid intake and adequate fluid intake must be maintained. Diagnosis of impaction/faecal loading of the rectum should be confirmed by physical or radiological examination of the abdomen and rectum.
8. g. oedema, shortness of breath, increasing fatigue, dehydration, cardiac failure) Macrogol compound powder for oral solution should be stopped immediately and electrolytes measured, and any abnormality should be treated appropriately.
5). Seizure Cases of seizures associated with use of macrogol 3350 with electrolytes for bowel preparation were observed in patients either with or without prior history of seizures. 8). Use caution when prescribing macrogol 3350 with electrolytes in patients with a history of seizures, at increased risk of seizure or at risk of electrolyte disturbance.
In case of neurologic symptoms, fluid and electrolyte abnormalities should be corrected. 8) of macrogol 3350 with electrolytes for bowel preparation has been reported post-marketing, mostly in elderly patients. Advise patients to stop administration and seek immediate medical assistance if they experience incoercible vomiting and subsequent chest, neck, and abdominal pain, dysphagia, hematemesis or dyspnoea.
Ischaemic colitis Post-marketing cases of ischaemic colitis, including serious, have been reported in patients treated with macrogol for bowel preparation. Macrogol should be used with caution in patients with known risk factors for ischaemic colitis or in case of concomitant use of stimulant laxatives (such as bisacodyl or sodium picosulfate).
Patients presenting with sudden abdominal pain, rectal bleeding or other symptoms of ischaemic colitis should be evaluated promptly. e. essentially ‘potassium-free’. This medicine contains 187 mg sodium per sachet, equivalent to 9% of the WHO recommended maximum daily intake of 2 g sodium for an adult.
1. Intestinal perforation or obstruction due to structural or functional disorder of the gut wall, ileus, severe inflammatory conditions of the intestinal tract, such as Crohn's disease and ulcerative colitis and toxic megacolon.
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
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This medicine contains up to 50 mg sorbitol in each sachet. The additive effect of concomitantly administered products containing sorbitol (or fructose) and dietary intake of sorbitol (or fructose) should be taken into account. The content of sorbitol in medicinal products for oral use may affect the bioavailability of other medicinal products for oral use administered concomitantly.
5. 5 Interaction with other medicinal products and other forms of interaction Macrogol raises the solubility of medicinal products that are soluble in alcohol and relatively insoluble in water. 4). g. anti-epileptics. Therefore, other medicines should not be taken orally for one hour before, during and for one hour after taking Macrogol compound powder for oral solution.
Macrogol compound powder for oral solution may result in a potential interactive effect when used with starch-based food thickeners. The polyethylene glycol (PEG) ingredient counteracts the thickening effect of starch, effectively liquefying preparations that need to remain thick for people with swallowing problems.
6 Fertility, Pregnancy and lactation Pregnancy There are limited amount of data from the use of Macrogol compound powder for oral solution in pregnant women. 3). Clinically, no effects during pregnancy are anticipated, since systemic exposure to macrogol 3350 is negligible.
Macrogol compound powder for oral solution can be used during pregnancy. Breastfeeding No effects on the breastfed newborn/infant are anticipated since the systemic exposure of the breast-feeding woman to macrogol 3350 is negligible.
Macrogol compound powder for oral solution can be used during breast- feeding. Fertility There are no data on the effects of Macrogol compound powder for oral solution on fertility in humans. 3). 7 Effects on ability to drive and use machines Macrogol compound powder for oral solution has no influence on the ability to drive and use machines.
8 Undesirable effects Reactions related to the gastrointestinal tract occur most commonly. These reactions may occur as a consequence of expansion of the contents of the gastrointestinal tract, and an increase in motility due to the pharmacologic effects of Macrogol compound powder for oral solution.
Mild diarrhoea, usually responds to dose reduction. The frequency of the adverse effects is not known as it cannot be estimated from the available data. System Organ Class Adverse Event Immune system disorders Allergic reactions, including anaphylaxis, angioedema, dyspnoea, rash, urticaria, and pruritus.
Skin and subcutaneous tissue disorders Erythema. Metabolism and nutrition disorders Electrolyte disturbances, particularly hyperkalaemia and hypokalaemia. Nervous system disorders Headache, seizure. […]
The maximum daily dose of this product is equivalent to 28% of the WHO recommended maximum daily intake for sodium. Macrogol compound powder for oral solution is considered high in sodium. This should be particularly taken into account for those on a low salt diet.
This medicine contains up to 50 mg sorbitol in each sachet. The additive effect of concomitantly administered products containing sorbitol (or fructose) and dietary intake of sorbitol (or fructose) should be taken into account. The content of sorbitol in medicinal products for oral use may affect the bioavailability of other medicinal products for oral use administered concomitantly.
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