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ISOPRENALINE MACURE is a brand name for Isoproterenol (also known as Isoprenaline). The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: Short-term treatment of permanent bradycardia due to atrio-ventricular block while pending a pacemaker or when a pacemaker is contraindicated. Short-term treatment of Adams-Stokes syndrome. National and international recommendations and guidelines on the appropriate use of isoprenaline should be followed.
Verbatim from this product's MHRA label. Tap a section to expand.
Isoprenaline Macure must only be administered by physicians trained in anaesthesia, cardiology or intensive care, in an appropriately monitored or critical care setting. Circulatory and respiratory functions should be closely monitored.
Isoprenaline should not be used routinely. Posology Isoprenaline Macure should be carefully titrated under close monitoring to the lowest possible dose that obtains a heart rate of 50-60 beats per minute. 01 microgram/kg/minute. 15 microgram/kg/minute.
The rate of infusion should be adjusted based on the heart rate of the patient.
Concomitant use with adrenaline:
Do not inject Isoprenaline Macure at the same time as adrenaline in any circumstances. 5). Method of administration Intravenous use. 6). This gives a concentration of 4 microgram/ml isoprenaline solution of infusion.
Serious adverse reactions to isoprenaline occur infrequently. Most adverse reactions subside rapidly when isoprenaline is discontinued or may abate while the drug is still in use. Isoprenaline has almost exclusively beta-agonist properties but also stimulates the CNS.
MedDRA frequency MedDRA-system organ class Not known (cannot be estimated from the available data) Cardiac disorders fast heartbeat arrhythmia precordial pain Vascular disorders low blood pressure high blood pressure Nervous system disorders nervousness shakiness dizziness headache Gastrointestinal disorders nausea General disorders and administration site conditions asthenia Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important.
It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.
• The use of Isoprenaline Macure requires ECG monitoring and reduction of doses in the case of ventricular myocardial hyperexcitability (polymorphic extrasystoles, repetitive burst pacing or ventricular tachycardia). • Isoprenaline Macure should be used with caution in hypovolemic patients.
• Caution when used in diabetic patients. • Caution when used on patients under the effect of digitalis. • In cases of hyperthyroidism, caution is recommended. Administration of the medicinal product should be avoided in cases of uncontrolled hyperthyroidism.
• Caution in cases of cardiovascular disorders, especially coronary insufficiency, arrhythmias and hypertension. • Caution in cases of convulsive disorders. • Caution when doses are sufficient to reach a heart rate greater than 130 beats per minute.
• Caution when using on patients who respond to sympathomimetic amines in an unusual manner. Isoprenaline Macure contains 16 mg sodium per ampoule. 8 % of the WHO recommended maximum daily intake of 2 g sodium for an adult.
1. 5) • Pre-existing ventricular arrythmias • Tachyarrythmias • Cardiac glycoside intoxication • Myocardial infarction • Angina pectoris
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
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Brand names are compiled from public regulatory records for active-ingredient mapping only. Drugvu is not affiliated with any manufacturer. This is not medical advice.