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DOXAPRAM HYDROCHLORIDE is a brand name for Doxapram. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: Doxapram acts as a ventilatory stimulant and Doxapram hydrochloride is used following anaesthesia to stimulate ventilation in the post-operative period as an aid to the reduction of post-operative pulmonary complications, and to permit the use of effective doses of narcotic analgesics without associated problems of…
Verbatim from this product's MHRA label. Tap a section to expand.
5mg/kg body weight, administered over a period of 30 seconds or more, which may be repeated at one-hour intervals, if necessary. Paediatric population Not recommended Hepatic impairment There are no studies to support dosage recommendations in patients with hepatic impairment.
4). Renal impairment There are no studies to support dosage recommendations in patients with renal impairment. Method of administration Doxapram hydrochloride is recommended for intravenous use only.
Adverse reactions listed by System Organ Class. The following adverse reactions have been observed at the frequencies defined using the following convention: Not known: cannot be estimated from the available data.
Nervous system disorders:
Doxapram hydrochloride may produce adverse effects due to general stimulation of the central, peripheral and autonomic nervous systems: pyrexia, sweating, flushing, salivation, headache, dizziness, hyperactivity, confusion, hallucinations, perineal warmth, muscle fasciculation, muscle spasticity, clonus, bilateral babinski, increased deep tendon reflexes and convulsions have been reported.
Doxapram can induce a significant decrease in maximal cerebral blood flow velocity.
Cardiac disorders:
Cardiovascular effects have been observed and include a moderate increase in blood pressure, arrhythmias, sinus tachycardia, bradycardia and extrasystoles, chest pain or chest tightness.
Respiratory, thoracic and mediastinal disorders:
Respiratory problems such as dyspnoea, cough, bronchospasm and laryngospasm may occur.
Gastrointestinal Disorders:
Effects on the gastrointestinal tract such as nausea and vomiting may also occur.
Renal and Urinary disorders:
Urinary retention, stimulation of urinary bladder with spontaneous voiding. 2). The following adverse reactions have been reported in off-licence use of doxapram in preterm neonates and infants: - neurodevelopmental delay - significant prolongation of QT interval, in some cases associated with atrioventricular block.
Doxapram hydrochloride should be administered concurrently with oxygen to patients with severe irreversible airways obstruction or severely decreased lung compliance, due to the increased work of breathing in these patients. - In patients presenting with bronchoconstriction, Doxapram hydrochloride should always be used in conjunction with β-adrenoceptor bronchodilator drugs in order to reduce the amount of respiratory effort.
- As Doxapram hydrochloride is metabolised primarily by the liver, use with care in patients with hepatic dysfunction. - Doxapram hydrochloride should be administered cautiously to patients receiving sympathomimetic agents since an additive pressor effect may occur.
- Doxapram hydrochloride should be used with great care in patients who are being treated concurrently with monoamine oxidase inhibiting drugs. Animal studies have shown that the action of doxapram is potentiated after pre- treatment with a MAOI.
- In patients who have received anaesthetics known to sensitize the myocardium to catecholamines, such as halothane, cyclopropane, and enflurane, initiation of doxapram hydrochloride therapy should be delayed for at least 10 minutes following discontinuance of anaesthesia, since an increase in adrenaline release has been noted with Doxapram hydrochloride administration.
- The respiratory stimulant effect of Doxapram hydrochloride may not outlast the residual effects of the depressant drugs. Since respiratory depression may recur after stimulation with Doxapram hydrochloride, the patient should be closely monitored until fully alert for ½ to 1 hour.
Doxapram hydrochloride may temporarily mask the residual effects of curare-type muscle relaxant drugs. - Doxapram hydrochloride should be administered with caution in patients with hypermetabolic states such as phaeochromocytoma. - If sudden hypertension or dyspnoea develops, Doxapram hydrochloride should be stopped.
1 - Severe hypertension - Status asthmaticus - Coronary artery disease - Epilepsy and other convulsive disorders - Cerebral oedema - Cerebrovascular accident - Hyperthyroidism /Thyrotoxicosis - Physical obstruction of the respiratory tract, or conditions resulting in restriction of chest wall, muscles of respiration or alveolar expansion.
- Head injury - Proven/suspected pulmonary embolism
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
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- Monitoring of the blood pressure and deep tendon reflexes is recommended to prevent overdosage. - To avoid side effects, it is advisable to use the minimum effective dosage. - Doxapram should not be used in conjunction with mechanical ventilation.
- An adequate airway is essential and airway protection should be considered since doxapram may stimulate vomiting. 3) and in patients with impaired cardiac reserve - The administration of this agent does not diminish the need for continuous monitoring of all aspects of patient response, including frequent analysis of arterial-blood gases.