CLEAREYES

Posology Adults and children 12 years and over:

The recommended dosage is one or two drops into each eye two or three times daily. 4). Paediatric population The safety and efficacy of Murine in children aged 0 to 12 years have not been established. No data are available. Page 2 of 7 Method of administration For ocular use If other eye drops/eye ointments are additionally being used, an interval of approximately 15 minutes should be observed between the doses and any eye ointment should always be applied last.

Adverse events which have been associated with naphazoline hydrochloride are given below, tabulated by system organ class and frequency.

Frequencies are defined as:

Very common (≥1/10); Common Page 4 of 7 (≥1/100 to <1/10); Uncommon (≥1/1000 to <1/100); Rare (≥1/10,000 to <1/1000); Very rare (< 1/10,000); Not known (cannot be estimated from the available data). Within each frequency grouping, adverse events are presented in order of decreasing seriousness.

Very occasionally transient eye irritation (including stinging and itching), transient blurred vision, and mydriasis (pupil dilation) have been reported. System Organ Class Frequency Adverse Events Immune System Disorders Not known Hypersensitivity Nervous System Disorders Not known Headache, dizziness Eye Disorders Not known Blurred vision, pupil dilation, eye irritation, eye pain, ocular hyperaemia1 Gastrointestinal Disorders Not known Nausea Description of Selected Adverse Reactions 1Following long term use a rebound secondary hyperaemia may occur.

Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

This product is for intermittent or occasional use only. Rebound effects have been reported after prolonged and/or excessive use of naphazoline containing eye drops. Patients who are being treated for high blood pressure, depression, heart disease, arteriosclerosis, diabetes or increased thyroid activity, should consult their doctor before using the drops as naphazoline may exacerbate vasoconstriction.

9). Murine should not be used if there is an eye condition characterised by continued redness, pain or blurring of vision. If there is any eye pain, vision changes, photophobia, continued redness or irritation of the eye, or if after 24 hours the condition worsens or shows no sign of improvement, discontinue use and consult a doctor.

Patients who have had eye surgery should not take Murine until they have been advised by a doctor that their recovery is complete. Use of naphazoline in the eye may liberate pigment granules from the iris, especially when given in high doses to elderly patients.

, desflurane, sevoflurane). Murine should not to be used in children younger than 12 years of age. Contains benzalkonium chloride which may cause eye irritation and is known to discolour soft contact lenses. Avoid contact with soft contact lenses; remove contact lenses prior to application and wait at least 15 minutes before re-insertion.

Benzalkonium chloride has been reported to cause eye irritation, symptoms of dry eyes and may affect the tear film and corneal surface. Should be used with caution in dry eye patients and in patients where the cornea may be compromised.

Page 3 of 7 If the solution changes colour or becomes cloudy do not use.

1. Murine is contraindicated in subjects with: angle-closure glaucoma, a narrow chamber angle (at risk for acute glaucoma), previous attacks of acute glaucoma due to a narrow chamber angle, iritis or corneal damage. This product must not be used prior to peripheral iridectomy in eyes susceptible to angle closure because mydriatic action may precipitate angle block.

5).