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CIMETIDINE is a brand name for Cimetidine. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: Cimetidine tablets are indicated for the oral treatment of benign gastric and duodenal ulcerations, stomal ulcer, reflux oesophagitis, Zollinger-Ellison syndrome, other conditions where gastric acid reduction is beneficial.
Verbatim from this product's MHRA label. Tap a section to expand.
The usual adult doses are 400mg twice daily (with breakfast and at night) or 200mg 3 times daily and 400mg at night or 800mg as a single daily dose at night. 4g daily in divided doses to maintain intragastric pH above. Doses of 20 - 40mg/kg in divided doses have been used in children.
The usual maintenance dose is 400mg at night or 400mg morning and night. In reflux oesophagitis and Zollinger-Ellison syndrome the dose is 400mg 4 times daily (continued in reflux oesophagitis for 8 weeks). 6g. In surgical procedures (prophylaxis of acid aspiration) 400mg 90 - 120 minutes before induction of anaesthesia supplemented when necessary.
A 1g daily dose in divided doses to reduce malabsorption and fluid loss is used in short-bowel syndrome; and similar dose used in patients receiving pancreatic enzyme supplements. Cimetidine tablets are given orally.
The drug is well tolerated and symptomatic side effects are rare. Cimetidine binds to androgen receptors, occasionally causes gynaecomastia and may, rarely, cause impotence. Confusion which rapidly reverses on stopping treatment, is also described particularly in elderly and severely ill patients.
Acute pancreatitis or thrombocytopenia may occur rarely and interstitial nephritis is another well described but rare effect. Headache, constipation, and nausea have been reported occasionally. In addition, some temporary increases in serum transaminases and gamma glutamyl transpeptidases have occurred.
Anaphylactoid reactions have occurred rarely. In a few patients decreases in white blood cell counts and thrombocytopenia have occurred. Reports of diarrhoea, rash and photosensitivity with the drug are of doubtful significance. Evidence that hypochlorhydria induced by H2 receptor blockade allows nitrosamine formation in the stomach and so could predispose to gastric cancer has been contested, and no coherent evidence exists to show that any clinical hazard arises.
Care should be exercised in patients with renal and hepatic impairment.
3. Contra-indications There are no known contraindications to Cimetidine.
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
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Brand names are compiled from public regulatory records for active-ingredient mapping only. Drugvu is not affiliated with any manufacturer. This is not medical advice.