Loading…
CEFAZOLIN is a brand name for Cefazolin. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: Cefazolin 2g Powder for solution for injection/infusion is indicated for the treatment of the following infections caused by cefazolin-susceptible micro-organisms: - skin and soft tissue infections - bone and joint infections. Perioperative prophylaxis. For surgical operations with increased risk of infections with…
Verbatim from this product's MHRA label. Tap a section to expand.
The dosage as well as the method of administration are dependent on the location and severity of the infection and on the clinical and bacteriological progress. Local therapeutic guidance should be taken into consideration. Adults and adolescents (above 12 years of age and ≥ 40 kg bodyweight) • Infections caused by sensitive micro-organisms: 1 g - 2 g cefazolin per day divided into 2-3 equal doses.
• Infections caused by moderately sensitive micro-organisms: 3 g - 4 g cefazolin per day divided into 3-4 equal doses. In severe infections, doses of up to 6 g per day can be administered in three or four equal doses (one dose every 6 or 8 hours).
5 - 1 g cefazolin during the intervention. • Prolonged continuation of administration beyond the surgical intervention should be supported by national official guidance. It is important that (1) the preoperative dose be given just (30 min to 1 hour) prior to the start of surgery so that adequate antibiotic levels are present in the serum and tissues at the time of initial surgical incision; and (2) cefazolin be administered, if necessary, at appropriate intervals during surgery to provide sufficient levels of the antibiotic at the anticipated moments of greatest exposure to infective organisms.
Adult patients with renal impairment Adults with renal impairment may need a lower dose to avoid overlapping. This lower dose may be guided by determining blood levels. If not possible, the dosage can be established based on creatinine clearance.
6 Half of the normal dose every 18-24 hours In haemodialysis patients, the treatment schedule depends on the dialysis conditions. Guidelines for adult dosage Reconstitution table for intravenous injection Content per vial Minimum amount of diluent to be added Approximate concentration 1 g 4 mL 220 mg / mL Paediatric population: Infections caused by sensitive microorganisms A dose of 25-50 mg / kg body weight divided into two to four equal doses per day is recommended (one dose every 6, 8 or 12 hours).
Infections caused by moderately sensitive microorganisms A dose of up to 100 mg / kg body weight divided in three or four equal doses is recommended (one dose every 6 or 8 hours). Prematures and infants below the age of 1 month Since safety of use in prematures and infants below the age of one month has not been determined, the use of Cefazolin 2g Powder for solution for injection/infusion in these patients is not recommended.
2). g. furosemide), at the same time. Intrathecal use Not for intrathecal administration. Severe intoxication of the central nervous system (including convulsions) has been reported following intrathecal administration of cefazolin. Bacterial resistance and superinfections Long-term treatment of cefazolin can result in cefazolin-resistant bacteria.
Patients should be closely monitored for potential superinfections. If these occur, appropriate measures should be taken. Coagulation disorders Treatment with cefazolin may lead to coagulation disorders in exceptional cases. Risk factors are vitamin K deficiency in patients or the effect of other coagulation mechanisms (parenteral nutrition, malnutrition, impaired hepatic and renal function, thrombocytopenia).
Blood clotting may also be impaired in the case of associated diseases (haemophilia, gastric and duodenal ulcers) that may cause or aggravate bleeding. Therefore, patients with these conditions should be monitored for their prothrombin time.
If there is a significant reduction, a vitamin K supplement (10 mg / week) should be administered. Hypertension or heart failure In patients with hypertension or heart failure the sodium content of the solution for injection should be taken into account.
Use of lidocaine:
In case a lidocaine solution is used as a solvent, cefazolin solutions must only be used for intramuscular injection. 3). The lidocaine solution should never be administered intravenously. Paediatric population Premature babies and infants below the age of one month Cefazolin must not be given to preterm babies and infants below the age of one month, as there has been no adequate relevant experience to date.
2 mg sodium per vial (2,000 mg), equivalent to 5% of the WHO recommended maximum daily intake of 2 g sodium for an adult. To be taken into consideration by patients on a controlled sodium diet. g. tetracyclines, sulphonamides, erythromycin, chloramphenicol) should be considered when these antibiotics are to be co-administered with cefazolin.
4. e. concentration approx. 180 mg / mL). The respective volume of this solution to be used is indicated in Table 1 in addition to the dose in mg. Intravenous administration of lidocaine solutions must be strictly avoided.
Table 1:
Appropriate volumes for intravenous injection for paediatric patients for Cefazolin 2 g powder for solution for injection/infusion. 5 mL syringe for better accuracy of dosing. 6. Paediatric patients with renal impairment Children with renal impairment (like adults) may need a lower dose to avoid overlapping.
This lower dose may be guided by determining blood levels. If not possible, the dosage may be determined based on creatinine clearance, according to the following guidelines. In children with moderate impairment (creatinine clearance 40 – 20 mL / min), 25% of the normal daily dose, divided into doses every 12 hours are sufficient.
In children with severe impairment (creatinine 20 – 5 mL / min) will be 10% of normal daily dose, given every 24 hours are sufficient. All these guidelines are valid after an initial starting dose. 4.
Elderly patients:
In elderly patients with normal renal function no dosage adjustment is necessary. Method of administration Cefazolin 2 g Powder for solution for injection/infusion may be administered by slow intravenous injection or by intravenous infusion after dilution.
Single doses exceeding 1 g should be given as intravenous infusion. The volume and type of diluent to be used for the reconstitution is dependent upon the method of administration. 6. 3). Τhe information in the Summary of Product Characteristics of lidocaine should be considered.
Duration of treatment The duration of the treatment depends on the severity of the infection as well as on the clinical and bacteriological progress. 3 Contraindications Hypersensitivity to cefazolin sodium. g. anaphylactic reaction) to other beta- lactam antibiotics (penicillins, monobactams and carbapenems).
Hypersensitivity to cefazolin sodium. g. anaphylactic reaction) to other beta- lactam antibiotics (penicillins, monobactams and carbapenems). 4). See information in the Summary of Product Characteristics of lidocaine, especially contraindications.
Cefazolin solutions containing lidocaine should never be administered intravenously.
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Know a brand we are missing in United Kingdom? Suggest a brand →
Brand names are compiled from public regulatory records for active-ingredient mapping only. Drugvu is not affiliated with any manufacturer. This is not medical advice.
See also section
Probenecid The renal clearance of cefazolin is reduced with concomitant administration of probenecid. Vitamin K1 Some cephalosporins such as cefamandole, cefazolin and cefotetan can cause interference in vitamin K1 metabolism, especially in cases of vitamin K1 deficiency.
This may require vitamin K1 replacement. 4). g. warfarin or heparin) in high doses, coagulation parameters must be monitored. In a large number of cases, an increase in oral anticoagulant activity has been reported in patients receiving antibiotics.
Infection and inflammation, age and general condition of the patient are likely to constitute risk factors. Under these circumstances, it is difficult to establish which role the infectious disease and its treatment play when INR imbalance occurs.
However, some classes of antibiotics are more implicated, particularly fluoroquinolones, macrolides, cyclins, cotrimoxazole and some cephalosporins. g. g. g. furosemide) is increased. When co-administered with cefazolin, kidney function tests must be carefully monitored.
Laboratory tests In laboratory tests, there may be a false-positive reaction for urinary glucose when using Benedict’s solution or Fehling’s solution in patients treated with cefazolin. Cefazolin has no effect on enzymatic measurements of glucose in urine.
The indirect and direct Coombs’ test can also give false-positive results. This may also apply to newborn babies whose mothers have been receiving cephalosporins. 6 Fertility, pregnancy and lactation Pregnancy Animal studies do not indicate direct or indirect harmful effects on reproductive toxicity.
Cefazolin should only be administered in pregnancy, especially during the first trimester, after careful benefit-risk assessment because there is insufficient experience and cefazolin crosses the placenta. It is preferable to avoid the use of cefazolin during pregnancy, unless it is absolutely necessary.
Breast-feeding Cefazolin is excreted in maternal milk at very low concentrations and therefore it should only be used after careful benefit/risk assessment. If diarrhoea or candidiasis should occur in the infant during breastfeeding, the mother should not breastfeed her infant during treatment, or else treatment with cefazolin should be discontinued.
Fertility Animal studies have shown no effects on fertility. 7 Effects on ability to drive and use machines Cefazolin has no influence on the ability to drive and use machines. 8) which may affect the ability to drive and use machines.
8 Undesirable effects Within each frequency grouping, undesirable […]
4). See information in the Summary of Product Characteristics of lidocaine, especially contraindications. Cefazolin solutions containing lidocaine should never be administered intravenously. 4 Special warnings and precautions for use Hypersensitivity Before therapy is initiated, it must be ascertained that the patient has shown no previous hypersensitivity following administration of cephalosporins, penicillins or other medicinal substances.
Cefazolin should be administered with caution in patients with a tendency to allergies. Cross-allergies between penicillins and cephalosporins have been documented. As with all beta-lactam antibacterial agents severe hypersensitivity reactions including fatal outcome have uncommonly been reported.
In the event of severe hypersensitivity reactions, treatment with cefazolin must be discontinued immediately and adequate emergency measures must be initiated. Prior to administration, it should be determined whether the patient has a past history of severe hypersensitivity reactions to cefazolin, other cephalosporins or any other type of beta-lactam agent.
Cefazolin should be used with caution in patients with a history of hypersensitivity reactions to other beta-lactams categorized as non-serious. Antibiotic-associated pseudomembranous colitis In cases of severe and persistent diarrhoea, considerations should be given to the possibility of antibiotic- related pseudomembranous colitis.
This condition can be life-threatening and therefore, treatment with cefazolin should be stopped immediately and appropriate therapy should be administered; antiperistaltic agents are contraindicated. 8 Undesirable effects. 2). Although cefazolin rarely causes renal dysfunction, it is recommended that renal function be monitored, especially in severely ill patients receiving maximum doses and in patients receiving […]