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BLICANZ THRUSH RELIEF is a brand name for Fluconazole. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: Fluconazole 150mg Capsules are recommended for the treatment of candidal vaginitis, acute or recurrent. It should also be used for the treatment of partners with associated candidal balanitis.
Verbatim from this product's MHRA label. Tap a section to expand.
Route of administration Oral. Fluconazole 150mg capsules should be swallowed whole In adults aged 16 - 60 years One capsule should be swallowed whole. In children - Not recommended in children aged under 16 years. Use in elderly - Not recommended in patients aged over 60 years.
Use in renal impairment- Fluconazole is predominantly excreted in the urine as unchanged active substance. No adjustments in single dose therapy are required.
4). The most frequently (≥1/100 to <1/10) reported adverse reactions are headache, abdominal pain, diarrhoea, nausea, vomiting, alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased and rash.
The following undesirable effects have been observed and reported during the treatment with fluconazole with the following frequencies: Very common (≥1/10); common (≥1/100 to < 1/10); uncommon (≥1/1000, < 1/100), rare (≥1/10000, < 1/1000) and very rare (>1/10000), not known (cannot be estimated from the available data).
4), dermatitis exfoliative, angioedema, face oedema, alopecia Drug reaction with eosinophilia and systemic symptoms (DRESS) Musculoskeletal and connective tissue disorders Myalgia General disorders and administration site conditions Fatigue, malaise, asthenia, fever *Fixed Drug Eruption Paediatric Population The pattern and incidence of adverse reactions and laboratory abnormalities recorded during paediatric clinical trials are comparable to those seen in adults.
Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.
4. Special warnings and special precautions for use Tinea capitis Fluconazole has been studied for treatment of tinea capitis in children. It was shown not to be superior to griseofulvin and the overall success rate was less than 20%.
Therefore, Fluconazole should not be used for tinea capitis. g. pulmonary and cutaneous cryptococcosis) is limited, which prevents dosing recommendations. Deep endemic mycoses The evidence for efficacy of fluconazole in the treatment of other forms of endemic mycoses such as paracoccidioidomycosis, lymphocutaneous sporotrichosis and histoplasmosis is limited, which prevents specific dosing recommendations.
2). Adrenal insufficiency Ketoconazole is known to cause adrenal insufficiency, and this could also although rarely seen be applicable to fluconazole. 5 ‘The effect of fluconazole on other medicinal products’. Hepatobiliary system Fluconazole should be administered with caution to patients with liver dysfunction.
Fluconazole has been associated with rare cases of serious hepatic toxicity including fatalities, primarily in patients with serious underlying medical conditions. In cases of fluconazole-associated hepatotoxicity, no obvious relationship to total daily dose, duration of therapy, sex or age of patients has been observed.
Fluconazole hepatotoxicity has usually been reversible on discontinuation of therapy. Patients who develop abnormal liver function tests during Fluconazole therapy should be monitored for the development of more serious hepatic injury.
The patient should be informed of suggestive symptoms of serious hepatic effect (important asthenia, anorexia, persistent nausea, vomiting and jaundice). Treatment of fluconazole should be immediately discontinued and the patient should consult a physician.
Cardiovascular system Some azoles, including fluconazole, have been associated with prolongation of the QT interval on the electrocardiogram. Fluconazole causes QT prolongation via the inhibition of Rectifier Potassium Channel current (Ikr).
1. Co-administration of terfenadine is contraindicated in patients receiving fluconazole at multiple doses of 400mg per day or higher based upon results of a multiple dose interaction study. 5).
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
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The QT prolongation caused by other medicinal products (such as amiodarone) may be amplified via the inhibition of cytochrome P450 (CYP) 3A4. During post- marketing surveillance, there have been very rare cases of QT prolongation and torsade de pointes in patients taking fluconazole.
These reports included seriously ill patients with multiple confounding risk factors, such as structural heart disease, electrolyte abnormalities and concomitant medications that may have been contributory. Patients with hypokalemia and advanced cardiac failure are at an increased risk for the occurrence of life threatening ventricular arrhythmias and torsades de pointes.
Fluconazole should be administered with caution to patients with these potentially proarrhythmic conditions. 5). Halofantrine Halofantrine has been shown to prolong QTc interval at the recommended therapeutic dose and is a substrate of CYP3A4.
5).
Dermatological reactions:
Patients have rarely developed exfoliative cutaneous reactions, such as Stevens - Johnson syndrome and toxic epidermal necrolysis, during treatment with fluconazole. AIDS patients are more prone to the development of severe cutaneous reactions to many medicinal products.
If a rash, which is considered attributable to Fluconazole, develops in a patient treated for a superficial fungal infection, further therapy with this agent should be discontinued. If patients with invasive/systemic fungal infections develop rashes, they should be monitored closely and Fluconazole discontinued if bullous lesions or erythema multiforme develop.
Drug reaction with eosinophilia and systemic symptoms (DRESS) has been reported. 5). 3) Cytochrome P450 Fluconazole is a moderate CYP2C9 inhibitor and CYP3A4 inhibitor. Fluconazole is also a strong inhibitor of CYP2C19. 5).
Candidiasis:
Studies have shown an increasing prevalence of infections with Candida species other than C. albicans. g. C. krusei and C. auris) or show reduced susceptibility to fluconazole (C. glabrata). Such infections may require alternative antifungal therapy secondary to treatment failure.
Therefore, prescribers are advised to take into account the prevalence of resistance in various Candida species to fluconazole. The product available from pharmacies without prescription will carry a leaflet that advises the patient: Do not use Fluconazole 150mg without first consulting your doctor: If you are under 16 or over 60 years of age.
If you are allergic to any of the ingredients in Fluconazole 150mg capsules or other antifungals and other thrush treatments. If you are taking any medicine other than the Pill. If you are taking the antihistamine terfenadine or the prescription medicine cisapride.
If you have had thrush more than twice in the last six months. If you have any disease or illness affecting your liver or kidneys have had unexplained jaundice. If you suffer from any other chronic disease or illness. If […]