ATROPINE SULFATE

2mg as a single night time dose. Elderly and Children Atropine should be used with caution employing a suitably reduced dose.

9) may also occur at therapeutic doses. Immune system disorders Hypersensitivity. In rare cases a fever may develop. Psychiatric disorders Confusional states (particularly in the elderly). Nervous system disorders Occasionally giddiness and staggering may occur.

Eye disorders Dilation of the pupils with loss of accommodation and photophobia. Increased intra- ocular pressure. In rare cases, angle-closure glaucoma may develop. Cardiac disorders Transient bradycardia, followed by tachycardia, palpitations and arrhythmias.

Respiratory, thoracic and mediastinal disorders Bronchial secretions may be reduced, with formation of mucous plugs. Gastrointestinal disorders Dry mouth with difficulty in swallowing, thirst. Occasionally nausea and vomiting may occur.

A reduction in the tone and mobility of the gastro-intestinal tract may lead to constipation. Increased gastric reflux may result in retrosternal pain. Skin and subcutaneous tissue disorders Flushing and dryness of the skin. Rashes. Renal and urinary disorders Urinary urgency, difficulty or retention.

Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard.

Use with caution in patients with urinary retention, acute myocardial infarction, hypertension, conditions associated with tachycardia (including hyperthyroidism, cardiac insufficiency, cardiac surgery), pyrexia and diarrhoea. Use of atropine in patients with ulcerative colitis may lead to toxic megacolon and ileus.

Increased side effects may be seen in children and the elderly, and in patients with Down’s syndrome. Atropine may aggravate gastro-oesophageal reflux. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

Atropine is contraindicated in patients with prostatic enlargement, as it may lead to urinary retention. Atropine should not be used in patients with paralytic ileus or pyloric stenosis. Atropine is contraindicated in angle-closure glaucoma or in patients with a narrow angle between the iris and the cornea as it may raise intra-ocular pressure and precipitate an acute attack.

Atropine is contra-indicated in myasthenia gravis (except to reduce muscarinic side- effects of anticholinesterases).