AMINOVEN

Posology The daily requirement of amino acids depends on the body weight and the metabolic conditions of the patient. The maximum daily dose varies with the clinical condition of the patient and may even change from day to day. The recommended infusion period is to provide a continuous infusion for at least 14 hours up to 24 hours, depending on the clinical situation.

Bolus administration is not recommended. The solution is administered as long as a parenteral nutrition is required. g. corresponding to 1120 - 1400 ml Aminoven 8 at 70 kg body weight/day. 1 g amino acids per kg body weight/hour). 0 g amino acids per kg body weight/day) corresponding to 70 g amino acids at 70 kg body weight.

For an increased amino acids dosage suitable preparations are available. Paediatric population No studies have been performed in the paediatric population. 3). For children under 2 years, paediatric amino acid preparations which are formulated to meet their different metabolic needs should be used.

Children and adolescents (2-18 years) Dosage:

The dose should be adjusted to hydration status, biological development and body weight.

Maximum infusion rate:

Same as for adults, see information above. 0 g amino acids per kg body weight/day) but total daily fluid intake must be considered. Method of administration For administration via a peripheral or central vein as a continuous infusion.

None known when correctly administered. 9) are usually reversible and regress when therapy is discontinued. Infusion via peripheral veins in general can cause irritation of the vein wall and thrombophlebitis. No clinical studies have been conducted.

Reporting suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard

Serum electrolytes, fluid balance and renal function should be monitored. In cases of hypokalemia and/or hyponatremia adequate amounts of potassium and/or sodium should be supplied simultaneously. Amino acid solutions may precipitate acute folate deficiency.

Therefore folic acid should be given daily. Care should be given if large volumes infused in patients with cardiac insufficiency. Infusion via peripheral veins in general can cause irritation of the vein wall and thrombophlebitis. Therefore, daily inspections of the insertion site are recommended.

If adjunction of lipid emulsions is indicated it should be administered where possible as a mixture with Aminoven 8 in order to minimise the risk of vein irritation. The choice of a peripheral or central vein depends on the final osmolarity of the mixture.

The general accepted limit for peripheral infusion is approx. 800 mosm/l, but it varies considerably with the age and the general condition of the patient and the characteristics of the peripheral veins. Strict asepsis should be maintained, particularly when inserting a central vein catheter.

Aminoven 8 is for use as part of total parenteral nutrition in combination with adequate amounts of energy supplements (carbohydrate solutions, lipid emulsions), electrolytes, vitamins and trace elements.

The administration of Aminoven 8 is contraindicated in children less than 2 years of age. As for all amino acid solutions the administration of Aminoven 8 is contra-indicated in the following conditions: Disturbances of amino acid metabolism, metabolic acidosis, renal insufficiency without haemodialysis or haemofiltration treatment, advanced liver insufficiency, fluid overload, shock, hypoxia, decompensated heart failure.