AMINOVEN

Posology The daily requirement of amino acids depends on the body weight and the metabolic conditions of the patient. The maximum daily dose varies with the clinical condition of the patient and may even change from day to day. The recommended infusion period is to provide a continuous infusion for at least 14 hours up to 24 hours, depending on the clinical situation.

Bolus administration is not recommended. The solution is administered as long as a parenteral nutrition is required. g. corresponding to 470 - 930 ml Aminoven 25 at 70 kg body weight/day. 1 g amino acids per kg body weight/hour). 0 g amino acids per kg body weight/day) corresponding to 140 g amino acids at 70 kg body weight.

Paediatric population No studies have been performed in the paediatric population. 3). Children and adolescents (2-18 years of age) are recommended to receive Aminoven 8 or Aminoven 16. For children under 2 years, paediatric amino acid preparations which are formulated to meet their different metabolic needs should be used.

Method of administration For administration via a central vein as a continuous infusion.

None known when correctly administered. 9) are usually reversible and regress when therapy is discontinued. Infusion via peripheral veins in general can cause irritation of the vein wall and thrombophlebitis. Clinical experience is very limited.

Reporting suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the national reporting scheme.

By reporting side effects, you can help provide more information on the safety of this medicine. ie

Serum electrolytes, fluid balance and renal function should be monitored. In cases of hypokalemia and/or hyponatremia adequate amounts of potassium and/or sodium should be supplied simultaneously. Amino acid solutions may precipitate acute folate deficiency.

Therefore folic acid should be given daily. Care given if large volumes infused in patients with cardiac insufficiency. The choice of a peripheral or central vein depends on the final osmolarity of the mixture. The general accepted limit for peripheral infusion is approx.

800 mosm/l, but it varies considerably with the age and the general condition of the patient and the characteristics of the peripheral veins. Strict asepsis should be maintained, particularly when inserting a central vein catheter. Aminoven 25 is for use as part of total parenteral nutrition in combination with adequate amounts of energy supplements (carbohydrate solutions, lipid emulsions), electrolytes, vitamins and trace elements.

The administration of Aminoven 25 is contraindicated in children. As for all amino acid solutions the administration of Aminoven 25 is contra-indicated in the following conditions: Disturbances of amino acid metabolism, metabolic acidosis, renal insufficiency without haemodialysis or haemofiltration treatment, advanced liver insufficiency, fluid overload, shock, hypoxia, decompensated heart failure.