ADDIPHOS

Posology Adults A daily requirement for phosphate during complete intravenous nutrition would normally be within the range 10-40 mmol. This can be met by using 5-20 ml of Addiphos. 5-30 mmol each of potassium and sodium. The infusion should be given intravenously at a rate corresponding to not more than 10 mmol K+ per hour so as to avoid hyperkalaemia and also within the maximum infusion rate for Vamin.

Paediatric population Dosage should be reduced appropriately according to age and weight. Method of administration Intravenous infusion after dilution. 6.

4 Undesirable effects There have been no reported undesirable effects observed during the administration of Addiphos. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important.

It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard

This preparation should not be administered undiluted. 1. Addiphos should not be used in patients with hyperkalaemia such as is associated with adrenal or severe renal insufficiency. It should not be given in the presence of dehydration without fluid replacement.

A cloudy solution or one containing a precipitate must not be used. 3 Special warnings and precautions for use Care should be exercised in patients with cardiac disease, diabetes mellitus, renal dysfunction or hepatic insufficiency.

Infusion of potassium may depress cardiac function and counteract the effects of digitalis. Simultaneous infusion of potassium and glucose will achieve a lower serum potassium level than when potassium is given alone. Plasma levels and clinical signs suggesting hyperkalaemia require discontinuation.

The addition of Addiphos should be performed aseptically immediately before the start of the infusion and should be used within 24 hours. Each vial of Addiphos is for single use only. It should be mixed well immediately after addition to the infusion solution.