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VANCOMYCIN HYDROCHLORIDE FOR is a brand name for Vancomycin, supplied as a powder for solution. The medicine, its uses, side effects and dosage are the same regardless of brand.
Verbatim from this product's HC label. Tap a section to expand.
Each dose should be administered at a rate of no more than 10 mg/min or over a period of at least 60 minutes.
Intravenous Dosage Adults:
The usual intravenous dose is 500 mg every 6 hours or 1 g every 12 hours. Other patient factors such as age or obesity may call for modification of the usual intravenous daily dose.
Adults with Impaired Renal Function:
To avoid toxic serum levels dosage adjustment is required in patients with impaired renal function. Since accumulation in such patients has been reported to occur over several weeks of treatment, serum levels should be checked regularly.
The dosage calculation may be made by using the following nomogram if the creatinine clearance value is known for most patients with renal impairment or the elderly: (Moellering et al. 1981) Vancomycin Hydrochloride for Injection, USP – Product Monograph Page 10 of 33 For functionally anephric patients on dialysis, the nomogram is not valid.
In order to achieve therapeutic serum levels promptly in such patients, a loading dose of 15 mg/kg of body weight should be given. 9 mg/kg/24 h. When only serum creatinine is available, the conversion of this value into estimated creatinine clearance may be accomplished by using the following formula based on sex, weight and age of the patient.
A steady state of renal function is represented by the serum creatinine. 85 x above value Neonates, Infants and Children: The dosage schedule which follows has been used. Infusions can be divided and incorporated in the child's 24-hour fluid requirement and should be infused over 60 minutes.
Infants and Neonates:
It is suggested that an initial dose of 15 mg/kg be administered followed by 10 mg/kg every twelve hours for neonates in the first week of life and every eight hours thereafter up to the age of one month. Each dose should be given over 60 minutes.
Close monitoring of serum concentrations of vancomycin may be warranted in these patients.
Children:
The usual intravenous dosage of vancomycin is 10 mg/kg given every six hours. The majority of patients with infections caused by organisms susceptible to the antibiotic demonstrate a therapeutic response by 48 to 72 hours. The total duration of therapy is determined by the type and severity of the infection and the clinical response of the patient.
In staphylococcal endocarditis, therapy for three weeks or longer is recommended. Vancomycin Hydrochloride for Injection, USP – Product Monograph Page 11 of 33 Oral Dose Vancomycin, when administered orally, is to be used only in the treatment of staphylococcal enterocolitis, and/or pseudomembranous colitis associated with toxigenic Clostridium difficile.
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Vancomycin in Canada.
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Brand names are compiled from public regulatory records for active-ingredient mapping only. Drugvu is not affiliated with any manufacturer. This is not medical advice.
Adults:
The usual daily dose for antibiotic-associated colitis and/or staphylococcal enterocolitis is 125 - 500 mg. orally every 6 - 8 hours for 7 - 10 days.
Children:
The usual daily dosage is approximately 40 mg/kg in 3 or 4 divided doses for 7 - 10 days. The total daily dose should not exceed 2 g.
Administration Intermittent Intravenous Infusion:
It is necessary to further dilute the reconstituted solution with 100 - 200 mL Normal Saline or D5W (dextrose in sterile water for injection). The infusion should be over a period of at least 60 minutes. See the RECONSTITUTION section for instruction.
Continuous Intravenous Infusion:
Only when intermittent infusion is not practical should continuous intravenous infusion be used. A concentration no greater than 10 mg/mL is recommended. An infusion of 10 mg/min or less is associated with fewer infusion-related adverse events.
Oral Administration:
By diluting the contents of the intravenous vial (500 mg) in 30 mL of water, the patient is permitted to drink the antibiotic or the solution may be administered via nasogastric tube. 68 g/mol Description: Vancomycin Hydrochloride for Injection, USP – Product Monograph Page 13 of 33 Vancomycin hydrochloride is an off-white to light-tan lyophilized plug.
5 when reconstituted in water. COMPOSITION Each vial contains vancomycin hydrochloride equivalent to 500 mg, 1 g, 5 g and 10 g vancomycin base. STABILITY AND STORAGE RECOMMENDATIONS Store the unreconstituted product between 15 °C and 30 °C.
RECONSTITUTION 500 mg vial:
The addition of 10 mL of Sterile Water for Injection provides a reconstituted solution containing approximate average vancomycin concentration of 50 mg/mL. 1 g vial: The addition of 20 mL of Sterile Water for Injection provides a reconstituted solution containing approximate average vancomycin concentration of 50 mg/mL.
5 g vial: The addition of 100 mL of Sterile Water for Injection provides a reconstituted solution containing approximate average vancomycin concentration of 50 mg/mL.
Note:
Further dilution is required. 10 g vial: The addition of 95 mL of Sterile Water for Injection provides a reconstituted solution containing approximate average vancomycin concentration of 100 mg/mL.
Note:
Further dilution is required. 9% Sodium […]