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TEVA-HYDROCHLOROTHIAZIDE is a brand name for Hydrochlorothiazide, supplied as a tablet. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: AND CLINICAL USE.............................................................................................. 3 CONTRAINDICATIONS ................................................................................................................. 4 WARNINGS AND PRECAUTIONS…
Verbatim from this product's HC label. Tap a section to expand.
Therapy should be individualized according to the patients requirement. Use the smallest dosage necessary to achieve the required response. Dosing Considerations Adult patients • Diuresis The recommended adult dosage is 50 mg to 100 mg once or twice a day.
e. administration on alternate days or on three to five days each week. With an intermittent schedule, excessive response and the resulting undesirable electrolyte imbalance are less likely to occur. • Toxemia of pregnancy The recommended dosage is 100 mg daily or, in severe cases and for brief periods, 200 mg daily (in divided doses).
Frequency of administration may range from once every four days to daily. • Premenstrual tension with edema The recommended dosage is 25 mg to 50 mg once or twice a day from the first appearance of symptoms until onset of the menses.
• Control of Hypertension The usual recommended starting dosage is 50 mg or 100 mg a day as a single or divided dose. Dosage is increased or decreased according to the blood pressure response of the patient. Some patients may require doses of 200 mg a day in divided doses.
Careful observation for changes in blood pressure must be made when TEVA- HYDROCHLOROTHIAZIDE (hydrochlorothiazide) is used with other antihypertensive drugs, especially during initial therapy. The dosage of other agents must be reduced by at least 50%, as soon as it is added to the regimen, to prevent excessive drop in blood pressure.
As the blood pressure falls under the potentiating effect of this agent, a further reduction in dosage, or discontinuation of other antihypertensive drugs may be necessary. 5 mg of hydrochlorothiazide could be used in combination with another antihypertensive.
5 mg may be effective (especially in the elderly or as a starting dose), as well as a daily dose of 25 mg given in two divided doses. 0 mg of TEVA-HYDROCHLOROTHIAZIDE per pound of body weight per day in two doses. 5 mg per pound per day in two doses.
5 mg daily in two doses. 5 mg to 100 mg daily in two doses. Dosage in both age groups should be based on body weight. (See WARNINGS AND PRECAUTIONS, Special Populations, TEVA-HYDROCHLOROTHIAZIDE Product Monograph Page 13 of 23 Pediatrics).
OVERDOSAGE Symptoms Overdosage of hydrochlorothiazide may produce diuresis accompanied with electrolyte imbalance (hypokalemia, hyponatremia and hypochloremic alkalosis) and dehydration. The symptoms are as follows: dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, gastrointestinal disturbances, menta1 confusion, delirium, convulsions, shock, coma.
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Hydrochlorothiazide in Canada.
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g. increased ventricular irritability). Hydrochlorothiazide may precipitate hepatic coma in patients with cirrhosis; increase the effect of other antihypertensive agents and decrease arterial responsiveness to norepinephrine. Treatment No specific antidote is available.
Treatment is symptomatic and supportive. Induce emesis or perform gastric lavage. Correct dehydration, electrolyte imbalance, hepatic coma, and hypotension by established procedures. Administer oxygen or artificial respiration for respiratory impairment.
For management of a suspected drug overdose, contact your regional poison control centre. ACTION AND CLINICAL PHARMACOLOGY Mechanism of Action Hydrochlorothiazide is a diuretic and an antihypertensive agent. The exact mechanism of the antihypertensive effect is unknown.
Hydrochlorothiazide has no effect on normal blood pressure. Hydrochlorothiazide affects the renal tubular mechanism of electrolyte reabsorption. It increases excretion of sodium and chloride in approximately equivalent amounts and reduces the rate of formation of solute-free water.
Natriuresis causes a secondary loss of potassium and bicarbonate.
Pharmacokinetics Absorption:
Hydrochlorothiazide is rapidly absorbed from the gastrointestinal tract. Onset of action after oral administration occurs in 2 hours and the peak effect at approximately 4 hours. Duration of action persists for approximately 6 to 12 hours.
Distribution:
The drug is distributed throughout the extracellular space and does not accumulate in TEVA-HYDROCHLOROTHIAZIDE Product Monograph Page 14 of 23 tissues other than the kidney. It passes readily through the placental barrier to the fetus.
Metabolism:
Hydrochlorothiazide is not metabolized.
Excretion:
Hydrochlorothiazide is eliminated rapidly by the kidney. STORAGE AND STABILITY TEVA-HYDROCHLOROTHIAZIDE (hydrochlorothiazide) tablets should be stored at controlled room temperature (15°C to 30°C) away from heat and light. DOSAGE FORMS, COMPOSITION AND PACKAGING TEVA-HYDROCHLOROTHIAZIDE (hydrochlorothiazide) tablets are available for oral use in two dosage strengths of 25 mg and 50 mg hydrochlorothiazide, USP.
Availability of Dosage Forms TEVA-HYDROCHLOROTHIAZIDE (hydrochlorothiazide) tablets are supplied as: 25 mg tablets: Small, light orange-colored, round, flat-faced, bevel-edged compressed tablets, with engraved bisect on one side and plain on the reverse.
Supplied in bottles of 100 and 1000 tablets. 50 mg tablets: Light orange-colored, round, flat-faced, bevel-edged compressed tablets, engraved novo on one side and 50 under bisect on the reverse. The tablets should not be split or divided.
Supplied in bottles of 100 tablets. Composition TEVA-HYDROCHLOROTHIAZIDE (hydrochlorothiazde) 25 mg and 50 mg tablets contain 25 mg, 50 mg of Hydrochlorothiazide, respectively. Non medicinal ingredients […]
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