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SULFAMETHOXAZOLE AND TRIMETHOPRIM is a brand name for Sulfamethoxazole, supplied as a solution. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: Sulfamethoxazole and Trimethoprim Injection, BP (sulfamethoxazole and trimethoprim solution for the preparation of intravenous infusions) has been effective in the treatment of infections associated with the following gram-positive and gram-negative organisms: Gram-Negative Organisms Haemophilus influenzae Neisseria…
Verbatim from this product's HC label. Tap a section to expand.
). 2 CONTRAINDICATIONS Sulfamethoxazole and Trimethoprim Injection, BP (sulfamethoxazole and trimethoprim): Product Monograph Page 6 of 42 PrSULFAMETHOXAZOLE AND TRIMETHOPRIM INJECTION, BP (Sulfamethoxazole and Trimethoprim) • is contraindicated in patients who are hypersensitive to this drug or to any ingredient in the formulation, including any non-medicinal ingredient, or component of the container.
For a complete listing, see
). Appropriate dosage adjustments should be made (see 4 DOSAGE AND ADMINISTRATION). 2 CONTRAINDICATIONS Sulfamethoxazole and Trimethoprim Injection, BP (sulfamethoxazole and trimethoprim): Product Monograph Page 6 of 42 PrSULFAMETHOXAZOLE AND TRIMETHOPRIM INJECTION, BP (Sulfamethoxazole and Trimethoprim) • is contraindicated in patients who are hypersensitive to this drug or to any ingredient in the formulation, including any non-medicinal ingredient, or component of the container.
For a complete listing, see 6 DOSAGE FORMS, STRENGTHS, COMPOSITION AND PACKAGING. • is contraindicated in patients with a history of drug-induced immune thrombocytopenia, with use of trimethoprim and/or sulfonamides, and in patients with documented megaloblastic anemia due to folate deficiency, evidence of marked parenchymal damage, or blood dyscrasias.
• is contraindicated in patients with marked renal impairment where repeated measurements monitoring plasma drug concentrations cannot be performed (see also 7 WARNINGS AND PRECAUTIONS, Renal). • is contraindicated in pregnant patients and in breastfeeding mothers, because sulfonamides pass the placenta and are excreted in the milk and may cause kernicterus.
• is contraindicated in premature babies and full term infants less than two months of age. • should not be given to patients with acute porphyria. 4 Drug-Drug Interactions, dofetilide). 3 SERIOUS WARNINGS AND PRECAUTIONS BOX Serious Warnings and Precautions • Sulfamethoxazole and Trimethoprim Injection, BP can cause severe skin reactions that may be life threatening including Steven-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), acute febrile neutrophilic dermatosis (Sweet’s syndrome) and acute generalised exanthematous pustulosis (AGEP) (see 7 WARNINGS AND PRECAUTIONS, Skin).
• Sulfamethoxazole and Trimethoprim Injection, BP can cause fulminant hepatic necrosis that may be life-threatening (see 7 WARNINGS AND PRECAUTIONS, Hepatic/Biliary/Pancreatic). • Sulfamethoxazole and Trimethoprim Injection, BP can cause agranulocytosis (see 7 WARNINGS AND PRECAUTIONS, Hematology).
). 2 Geriatrics Geriatrics: Based on the data submitted and reviewed by Health Canada, the safety and efficacy of trimethoprim-sulfamethoxazole injection in geriatric patients have been established; therefore, Health Canada has authorized an indication for geriatric use.
However, there may be an increased risk of severe adverse reactions in elderly patients, particularly when complicating conditions exist (see 7 WARNINGS AND PRECAUTIONS and 8 ADVERSE REACTIONS). Appropriate dosage adjustments should be made (see
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Sulfamethoxazole in Canada.
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Brand names are compiled from public regulatory records for active-ingredient mapping only. Drugvu is not affiliated with any manufacturer. This is not medical advice.
• Sulfamethoxazole and Trimethoprim Injection, BP can cause aplastic anemia (see 7 WARNINGS AND PRECAUTIONS, Hematology). • Sulfamethoxazole and Trimethoprim Injection, BP can cause immune thrombocytopenia that may be life-threatening (see 7 WARNINGS AND PRECAUTIONS, Immune).
• Sulfamethoxazole and Trimethoprim Injection, BP can cause an allergic reaction in the lungs and in the airways that may be life-threatening (see 7 WARNINGS AND PRECAUTIONS, Respiratory). 1 Dosing Considerations Sulfamethoxazole and Trimethoprim Injection, BP may be used only in patients who are unable to take oral medication or where there is a need for rapid attainment of high serum concentrations.
Oral treatment should be substituted as soon as possible. 2 Recommended Dose and Dosage Adjustment Serious Systemic Infections Adults The intravenous dosage of Sulfamethoxazole and Trimethoprim Injection, BP depends on the severity of the infection.
A dose of 160 to 240 mg trimethoprim + 800 to 1200 mg sulfamethoxazole may be given every 6, 8 or 12 hours. This dose must be properly diluted (see 13 PHARMACEUTICAL INFORMATION) and infused over a period of 30 minutes to 1 hour. Children The recommended daily dosage for children is 5 to 10 mg trimethoprim/kg body weight/day and 25 to50 mg sulfamethoxazole/kg body weight/day.
This daily dosage must be properly diluted and administered in equally divided doses by infusion over a period of 30 minutes to 1 hour. 1 Pediatrics). 5 * Sulfamethoxazole and Trimethoprim Injection, BP must be properly diluted (see 13 PHARMACEUTICAL INFORMATION) and administered in equally divided doses.
The daily dosage of Sulfamethoxazole and Trimethoprim Injection, BP must be given in two equally divided doses. Treatment should be continued until the patient has been symptom free for two days; the majority willrequire treatment for at least five days.
Other diseases, including certain tropical diseases rarely seen in Canada have also been successfully treated with Sulfamethoxazole and Trimethoprim Injection, BP.
The duration of treatment is as follows:
Product Monograph Page 8 of 42 PrSULFAMETHOXAZOLE AND TRIMETHOPRIM INJECTION, BP (Sulfamethoxazole and Trimethoprim) Disease Duration Cholera 7 days Nocardiosis 12 weeks Brucellosis 2 weeks to 3 months Pneumocystis jiroveci Pneumonitis Children and Adults The recommended daily intravenous dosage is 20 mg trimethoprim/kg body weight + 100 mg sulfamethoxazole/kg body weight.
This daily dosage is to be divided into 4 equal doses infused over a period of 30 minutes to 1 hour, at 6-hour intervals, until oral therapy can be instituted. 0 * Sulfamethoxazole and Trimethoprim […]